Results 141 to 150 of about 35,801,857 (245)

Dietary Patterns and Cardiovascular Diseases in Individuals with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Prospective Observational Studies. [PDF]

Adv Nutr
Barbaresko J, Kannenberg L, Schaefer E, Lang A, Schwingshackl L, Neuenschwander M, Schlesinger S.   +6 more
europepmc   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

Glial neurovascular unit protein dysregulation and risk of idiopathic intracranial hypertension: A systematic review and meta-analysis. [PDF]

Ger Med Sci
Arora B, Nath M, Tangri P, Kumar P, Singh RK, Singh GP, Vibha D, Srivastava AK, Garg D, Agarwal A, M R D, V Y V, Pandit AK.   +12 more
europepmc   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

From gut to brain: data-driven evidence suggests causal contribution of gut-microbiota to major depressive disorder in humans. [PDF]

Gut Microbes
Fehse L, Ribeiro AH, Winter NR, Thanarajah SE, Fisch L, Welzel M, Bang C, Meinert S, Flinkenflügel K, Borgers T, Goltermann J, Leehr EJ, Bloemendaal M, Natasha EE, Mulder D, Arias Vasquez A, Stein F, Thomas-Odenthal F, Usemann P, Teutenberg L, Nenadic I, Straube B, Alexander N, Jamalabadi H, Jansen A, Nitsch R, Lügering A, Reif A, Kittel-Schneider S, Cryan J, Franke A, Valderrama B, Clarke G, Lavelle A, Dannlowski U, Kircher T, Heider D, Hahn T.   +37 more
europepmc   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Transforming GP practices into multiprofessional primary care centers: The role of nursing professionals (PRIMA) - study protocol for a multicenter non-randomized, controlled, parallel-group intervention study. [PDF]

PLoS One
Naß P, Schüttig W, Flothow A, Coors M, Sundmacher L, Stolz R, Klein A, Joos S, An der Heiden I, Jöchner AK, Nolting HD, Haumann H, PRIMA Study Group.   +12 more
europepmc   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

Aortic disease-linked mutations reveal unexpected convergent allosteric mechanisms of protein kinase G misregulation. [PDF]

Sci Adv
Martinez Pomier K, Jahn L, VanSchouwen B, Mohamed H, Akimoto M, Jung SW, Bertinetti D, Mehringer J, Della Libera L, Cuello F, Herberg FW, Melacini G.   +11 more
europepmc   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source