Results 151 to 160 of about 35,801,857 (245)

Multiomic profiling links L1 retrotransposition to genomic instability and ecDNA in bladder cancer. [PDF]

Nat Commun
Pribus SJ, Osredek I, Otoničar J, Simovic-Lorenz M, Giovenino C, Rademacher A, Wille SJ, Berzain Battioni C, Scherer M, Manzano-Sanchez S, Kienzle A, Parekh U, Villacorta L, Benes V, Sant P, Mallm JP, Brand K, Rippe K, Riemer AB, Sültmann H, Plass C, Stankovic M, Korbel JO, Rausch T, Ernst A.   +24 more
europepmc   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

The 90-day blind spot: A surgical imperative after Kuehn and colleagues. [PDF]

JTCVS Tech
Khalpey Z.
europepmc   +1 more source

Multiscale Coupling From Mastication to Retronasal Aroma Perception: The PG‐DTCFN Model and Multiphysics Simulation

Advanced Science, EarlyView.
Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen, Xiongfeng He, Zihao Li, Zidong Chen, Jiajin Sun, Xinyu Jiang, Yunhui Zhang, Lizhang Wu, Ran Wang, Jingnan Lu, Bo Wang, Kezhou Cai, Baocai Xu   +12 more
wiley   +1 more source

Volumetric reference data of the orbit: a deep learning MRI analysis in the German national cohort. [PDF]

Sci Rep
Farassat N, Reisert M, Rospleszcz S, Rod JE, Böhringer D, Kroencke T, Niendorf T, Pischon T, Völzke H, Ringhof S, Reinhard T, Bamberg F, Lagrèze WA, Schlett CL, Wornath K, Molina-Fuentes MF.   +15 more
europepmc   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

circVDJ-seq for T cell clonotype detection in single-cell and spatial multi-omics. [PDF]

Genome Med
Plumbom I, Obermayer B, Raspe R, Pascual-Reguant A, Theurillat I, Pentimalli TM, Hsieh YH, Gil M, Dietrich C, Seeger-Zografakis M, Quedenau C, Wilde J, Braeuning C, Fischer C, Schuelke M, Seitz V, Ludwig LS, Eggert A, Rajewsky N, Borodina T, Beule D, Altmueller J, Radbruch H, Hauser AE, Conrad T.   +24 more
europepmc   +1 more source

A Pan‐Methylome Framework for Population‐Scale Bacterial Epigenomics

Advanced Science, EarlyView.
A scalable quantitative framework unlocks population‐level comparative epigenomics in bacteria. By transforming site‐level data into standardized traits, this approach reconstructs methylation‐informed phylogenies and defines the core epigenome.
Bin Ma, Huimin Gong, Ran Zhuo, Zaixiao Rao, Yanxi Wan, Mingyang Wang, Zahra Zeinalzadeh, Yuan Gao, Aohan Guan, Xinrun Li, Wanting Chen, Xiliang Wang, Yun Wan, Sihua Zhang, Yuncai Xiao, Qi Huang, Paul R. Langford, Xiangru Wang, Rui Zhou, Rui Luo, Hongbo Zhou, Chengliang Zhu, Hui Jin   +22 more
wiley   +1 more source

Saving faces is not enough: Mental health must become core noma care. [PDF]

PLOS Ment Health
Fastenau A.
europepmc   +1 more source

Constitution and by-laws of the Medical Association of Texas ...

The constitution for the Medical Association of Texas which includes the minute of the previous meeting as well as an address delivered by George Cupples.Full catalog title: Constitution and by-laws of the Medical Association of Texas : proceedings of ...
Medical Association of Texas; Cupples, George, 1815-1895
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