Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo +12 more
wiley +1 more source
LGBTIQ + people in palliative and end-of-life care contexts in Switzerland: a scoping review. [PDF]
Deml MJ +7 more
europepmc +1 more source
Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang +25 more
wiley +1 more source
Utilization of interdisciplinary in-hospital early rehabilitation in COVID-19 patients - a multicenter cohort study in the National Pandemic Cohort Network (NAPKON) in Germany. [PDF]
Liebl ME +22 more
europepmc +1 more source
The model shows the probiotics screening and underlying mechanisms of F. rodentiumn in alleviating IR‐induced tissue injury. Stress‐induced STAT3 mitochondria localization decreases F. rodentium abundance and butyrate concentration. Supplementation of F.
Hanyong Zhu +17 more
wiley +1 more source
General practitioners' involvement in inpatient medical rehabilitation in Germany: a scoping review. [PDF]
Klemmt M, van Baal K, Bonin M, Stiel S.
europepmc +1 more source
Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice
Aging causes accumulation of p16⁺ senescent cells that promote inflammation and dysfunction. Multi‐omics analyses reveal striking sex differences in senescent cell burden and clearance: females accumulate more p16⁺ cells, especially in the liver, and their removal rejuvenates molecular and functional profiles.
Yao Lin +4 more
wiley +1 more source
A scoping review of guidelines and resources to promote evidence based prescribing for older people with sensory impairment. [PDF]
Morrison BC +3 more
europepmc +1 more source
Aceso: Journal of the Boston University School of Medicine Historical Society [PDF]
Bleeker, Griffin +8 more
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