Results 221 to 230 of about 37,535,730 (255)

Quantitative Visualization of Intracellular Nanometabolism Using Peak‐Shifted Dual‐State Emissive FRET Nanoprobes

Advanced Science, EarlyView.
This study reveals the long‐elusive intracellular dissolution mechanism of carrier‐free nanomedicines. By utilizing peak‐shifted dual‐state emissive FRET nanoprobes (PDFNPs) that undergo a distinct ratiometric fluorescence peak shift upon disassembly, we achieve real‐time, quantitative tracking of dissolution kinetics in live cells.
Farsai Taemaitree, Jinwoo Sung, Yutaro Miki, Ryuju Suzuki, Yoshitaka Koseki, Kunikazu Ishii, Minsang Kim, Keita Tanita, Kota Sato, Toru Nakazawa, Satoshi Katsube, Daisuke Unabara, Tasuku Hamaguchi, Keisuke Kawakami, Koji Yonekura, Akihide Hibara, Atsushi Wakamiya, Hiroshi Uji‐I, Hitoshi Kasai   +18 more
wiley   +1 more source

Optimizing Emergency Department Care for People With Bleeding Disorders: A Scoping Review of Barriers and Interventions for Improvement. [PDF]

Haemophilia
Guo LY, Lorenzetti DL, Rydz N, Goodyear D, Hews-Girard J, Mok G, Khalife R, Uminski K.   +7 more
europepmc   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

Correlates of social participation of children with special healthcare needs: baseline of the PART-CHILD study. [PDF]

BMC Pediatr
Fioroni Ribeiro da Silva C, Herrler A, Wirth M, Weyers S, De Bock F.   +4 more
europepmc   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

AI for prognostic assessment of diffuse large B-cell lymphoma using H&E whole-slide images. [PDF]

Hemasphere
Lippl J, Reinke S, Schrod S, Wolfseher L, Hüttl P, Huttner M, Staiger AM, Oschlies I, Koch K, Michaelis EG, Richter J, Rauert-Wunderlich H, Seifert N, Kosch R, Schmitz N, Ziepert M, Thurner L, Poeschel V, Glaß B, Trümper L, Held G, Scott DW, Rosenwald A, Ott G, Spang R, Altenbuchinger M, Klapper W.   +26 more
europepmc   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Exploratory analysis of nasal and gut microbial community structure in preschool children with recurrent wheeze. [PDF]

Microb Ecol
Gschwendtner S, Maison N, Illi S, von Mutius E, Rosenboom I, Tümmler B, Dittrich AM, Weckmann M, Abdo M, Waschki B, Kopp MV, Hansen G, Brinkmann F, Rabe K, Schaub B, Schloter M, the ALLIANCE Study Group.   +16 more
europepmc   +1 more source

The burden of hospital-acquired legionellosis in German teaching hospitals. [PDF]

Infection
Kramme S, Ebner W, Lösslein A, Maier B, Schneider C, Liese J, Brandt C, Heininger A, von Baum H, Donker T, Reuter S, Henneke P, Baden-Württemberg Hospital Infection Prevention Group (BW-HIP).   +12 more
europepmc   +1 more source