Results 201 to 210 of about 37,535,730 (255)

circVDJ-seq for T cell clonotype detection in single-cell and spatial multi-omics. [PDF]

Genome Med
Plumbom I, Obermayer B, Raspe R, Pascual-Reguant A, Theurillat I, Pentimalli TM, Hsieh YH, Gil M, Dietrich C, Seeger-Zografakis M, Quedenau C, Wilde J, Braeuning C, Fischer C, Schuelke M, Seitz V, Ludwig LS, Eggert A, Rajewsky N, Borodina T, Beule D, Altmueller J, Radbruch H, Hauser AE, Conrad T.   +24 more
europepmc   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Volumetric reference data of the orbit: a deep learning MRI analysis in the German national cohort. [PDF]

Sci Rep
Farassat N, Reisert M, Rospleszcz S, Rod JE, Böhringer D, Kroencke T, Niendorf T, Pischon T, Völzke H, Ringhof S, Reinhard T, Bamberg F, Lagrèze WA, Schlett CL, Wornath K, Molina-Fuentes MF.   +15 more
europepmc   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Assessing the change in diet from baseline to first re-examination - results from the German National Cohort (NAKO). [PDF]

BMC Nutr
Wawro N, Knüppel S, Weber KS, Lieb W, Stürmer P, Schlesinger S, Leitzmann M, Fischer B, Castell S, Schmidt B, Hebestreit A, Loganathan G, Pischon T, Nimptsch K, Krist L, Willich SN, Peters A, Karch A, Teismann H, Obi N, Gastell S, Jaskulski S, Schulze MB, Linseisen J.   +23 more
europepmc   +1 more source

An Optimized Freeze‐Dry Multimodal Workflow for Sequential Micro‐CT Imaging, Histology, and Molecular Profiling: A Use Case in Human Liver Fibrosis

Advanced Science, EarlyView.
Optimized freeze‐drying and eosin staining deliver artifact‐free micro‐CT images of liver tissue at near‐histological detail, then hand the same specimen back for sectioning, staining, and sequencing. Fibrotic volume distinguishes normal liver from cirrhosis, while preserved RNA reveals inflammatory gene upregulation—one biopsy, three dimensions, and a
Kristijan Skok, Laura Činč Ćurić, Jernej Vajda, Silvia Schauer, Martin Wagner, Rudolf Stauber, Carolin Lackner, Karl Kashofer, Markus Plass, Giovanny Rodriguez Blanco, Ian R. Wanless, Uroš Maver, Katrin Panzitt, Boštjan Vihar   +13 more
wiley   +1 more source

Saving faces is not enough: Mental health must become core noma care. [PDF]

PLOS Ment Health
Fastenau A.
europepmc   +1 more source

Constrained Forest Methane Sink by Thermal Adaptation of Soil Methanotrophs

Advanced Science, EarlyView.
Climate warming can stimulate methanotroph‐mediated CH4 oxidation in forest soils, thereby mitigating the increase in atmospheric CH4 concentrations. By integrating evidence from a macro‐climatic thermal gradient and a 70‐day incubation experiment, this study demonstrates that microbial methanotrophs can adapt to long‐term temperature changes at the ...
Baizhi Jiang, Xi Zhang, Zhenghu Zhou, Nianpeng He, Xuhui Zhou, Hongyang Chen   +5 more
wiley   +1 more source

Tandem repeat polymorphisms are associated with brain structure: results of two large population-based studies. [PDF]

Genome Med
Mantey R, Hu J, Touhidinia M, Butt T, Sidky AM, Sobhani R, Estrada S, Haendler K, De Domenico E, Beyer MD, Breteler MMB, Aziz NA.   +11 more
europepmc   +1 more source

DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT

Advanced Science, EarlyView.
DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang   +17 more
wiley   +1 more source