Results 191 to 200 of about 35,801,857 (245)

Spatial and multi-omic profiling reveals pericyte-derived CCL19 as a key prognostic factor in CNS lymphoma. [PDF]

Hemasphere
Kuehn JC, Miarka L, Sankowski R, Mutter J, Neidert NN, Grabis E, Zhang J, Klingler C, Hummel F, Ranganathan L, Bleul S, Lauer EM, Heiland DH, Müller K, Reinhardt HC, Dietrich S, Illerhaus G, von Baumgarten L, Alig S, Diehn M, Sajonz BEA, Beck J, Coenen VA, Prinz M, Schorb E, Alizadeh AA, Duyster J, Reinacher P, Scherer F.   +28 more
europepmc   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

National Competence Based Catalogue of Learning Objectives for Undergraduate Medical Education (NKLM) - process description over the last 15 years. [PDF]

GMS J Med Educ
Jennebach J, Özkaya J, Giesecke S, Meißner N, Seidel M, Wyszynski V, Giesecke J, Rech T, Fritze O, Schildmann J, Kreuder J, Hickel R, Hahn EG, Fischer MR, Ahlers O.   +14 more
europepmc   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Euglena gracilis as a high-throughput screening platform for antibacterial activity, cytotoxicity and membrane permeability in a one-step and cost-effective assay. [PDF]

J Antibiot (Tokyo)
Pereira L, Löffler LS, H Kirsch S, Stadler M, Sandargo B, Holetz F, Müller R, Kramer S.   +7 more
europepmc   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Follow-Up Care after Adult Lung Transplantation: Summary of an Evidence-Based Clinical Practice Guideline for German-Speaking Countries.

Respiration
Gottlieb J, Wald A, Bucher B, Tapp B, Hirsch C, Schneider C, Winter H, Wilkens H, Geldmacher H, Hettich I, Jaksch P, Schuurmans MM, Schiffer M, Hecker M, Nothacker M, Skoetz N, Kreuzberger N, Witzke O, Schmitt R, Jörger-Tuti S, Bessa V, Veit W, Taube C, Kneidinger N.   +23 more
europepmc   +1 more source

Influence of general practice education on medical students' attitude towards this discipline: a mixed studies scoping review protocol. [PDF]

BMJ Open
Schürmann L, Höft LM, Karpfinger J, Gerbaulet S, Sternal J, Muth C, Puzhko S, Leeuw B, Peters T.   +8 more
europepmc   +1 more source

Stacking Pressure‐Driven Interfacial Dynamics in Anode‐Free Solid‐State Lithium Batteries

Advanced Science, EarlyView.
Using a three‐electrode setup, it is found that stacking pressure improves both anode and cathode interfaces but more effectively stabilizes the anode. Under low pressure, a sudden anode resistance rise indicates contact loss. Higher pressure delays this via Li creep and plastic deformation, maintaining interfacial contact.
Jianneng Liang, Matthias Bohnen, Ralf Müller, Robert Leiter, Simon Fleischmann, Shuya Gong, Mervyn Rohit Soans, Stefano Passerini, Alberto Varzi   +8 more
wiley   +1 more source

Bat-Associated Parvoviruses: High Genetic Diversity and Novel Viruses in Gia Lai and Dong Nai Provinces, Vietnam. [PDF]

Viruses
Lapshina VK, Gorbacheva AA, Nikolaeva PA, Grigoryan DA, Stetsenko IF, Luong MT, Tran TV, Yuzefovich AP, Prikhodko IO, Alekseev AY, Yudin SM, Shipulin GA, Matsvay AD, Skvortsova VI.   +13 more
europepmc   +1 more source