Results 181 to 190 of about 29,593 (220)

DNA methylation signatures associated with bipolar disorder in peripheral blood improve prediction models. [PDF]

EBioMedicine
Tesfaye M, Stavrum AK, Höffler KD, O'Connell KS, David FS, Garrett ME, Hesam-Shariati S, Overs BJ, Pisanu C, Spano L, Watkeys OJ, Weihs A, Ardau R, Ashley-Koch AE, Athanasiu L, Beckham JC, Bourassa KJ, Chillotti C, Djurovic S, Drange OK, Frank J, Khayachi A, Kimbrel NA, Martorell L, Meinert S, Melle I, Morken G, Paribello P, Pinna M, Roberts G, Rouleau G, Schofield PR, Sepúlveda E, Severino G, Steen VM, Stein F, Streit F, VA Mid-Atlantic MIRECC Workgroup, Lagerberg TV, Alda M, Dannlowski U, Forstner AJ, Fullerton JM, Grabe HJ, Green MJ, Kircher T, Labad J, Manchia M, Mitchell PB, Soares JC, Squassina A, Teumer A, Tondo L, Vilella E, Andreassen OA, Chaumette B, Fries GR, Le Hellard S.   +57 more
europepmc   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

HLA-DRB1*15:01 is associated with a reduced likelihood of longevity in northern European men. [PDF]

Genome Med
Mendoza-Mejía N, Kolbe D, Özer O, Dose J, Torres GG, Franke A, Nygaard M, Nebel A.   +7 more
europepmc   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Impact of the COVID-19 pandemic on diagnosis, and healthcare utilization, among patients with cancer (lung, breast, and pancreas) and cardiovascular diseases (HF, AF, hypertensive, and chronic ischemic heart disease) in Germany: two systematic reviews. [PDF]

Syst Rev
Ropeter J, Overhageböck N, Dreier M, Meyerdierks D, Imran A, Heinsohn T, Steinmann M, Kuhlmann A, Jahn B, Lange B, Klett-Tammen CJ, Harries M.   +11 more
europepmc   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Perioperative Antibiotic Prophylaxis in Cesarean Section and the Maternal Gut Microbiome: Protocol for a Remote Observational Cohort Study. [PDF]

JMIR Res Protoc
Feles EA, Mattner F.
europepmc   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Methodologies and methods for the development, evaluation and implementation of psychosocial interventions for dementia: protocol for a scoping review. [PDF]

BMJ Open
D'Andrea F, Bartels SL, Markaryan M, Masterson-Algar P, Bernal AN, De Bruin SR, Chirico I, Flynn A, Garcia L, Gebhard D, Handley M, Janssen N, Roes M, Stephens N, Teesing G, Van den Block L, Windle K, Moniz-Cook E, Graff M.   +18 more
europepmc   +1 more source

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source