Results 251 to 260 of about 343,979 (290)
Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota
Advanced Science, EarlyView.This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.Ruihong Guo, Zihua Guo, Yi Zhou, Yunhui Zhang, Haojin Cheng, Rebecca Devine, Chuang Sun, Ronghua Liu, Yanfen Zheng, Andrew J. Gates, Jonathan D. Todd, Xiao‐Hua Zhang +11 morewiley +1 more sourceTranslational Insights Into Myocardial Deformation and Fibrosis in Hypertrophic Cardiomyopathy Using Diffusion Tensor MRI. [PDF]
JACC AdvLaghzali O, Kara D, Chen S, Liu S, Shalikar S, Rusu MC, Qadri F, Carrier L, Yang HJ, Niendorf T, Ku MC, Nguyen C. +11 moreeuropepmc +1 more sourceLactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian +16 morewiley +1 more sourceLarge-scale meta-analysis and precision functional assays identify FANCM regions in which PTVs confer different risks for ER-negative and triple-negative breast cancer. [PDF]
BreastBillaud A, Figlioli G, Mooser C, Casamassima I, Azzoni V, Srivatsa J, Colombo M, Caleca L, Ahearn TU, Andrulis IL, Antoniou AC, Beckmann MW, Behrens S, Bermisheva M, Bogdanova NV, Bolla MK, Bonanni B, Brüning T, Camp NJ, Campbell A, Castelao JE, Cessna MH, Chang-Claude J, NBCS Collaborators, Czene K, Dennis J, Devilee P, Dörk T, Dunning AM, Eriksson M, Evans DG, Fasching PA, Figueroa JD, Gabrielson M, Gago-Dominguez M, González-Neira A, Guénel P, Hadjisavvas A, Hahnen E, Hamann U, Hillemanns P, Hollestelle A, Hooning MJ, Hoppe R, Howell A, kConFab Investigators, Jakubowska A, Kristensen VN, Lubiński J, Lush M, Manoukian S, Mavroudis D, Milne RL, Mulligan AM, Newman WG, Obi N, Panayiotidis MI, Pita G, Rashid MU, Rhenius V, Saloustros E, Sawyer EJ, Schmutzler RK, Shah M, Southey MC, Spurdle AB, Tomlinson I, Truong T, Wang Q, Wendt C, Auer PL, Boddicker NJ, Bodelon C, Burnside ES, Chen F, Couch FJ, Domchek SM, Eliassen HA, Haiman C, Hodge JM, Hu C, Huang H, Lindstrom S, Martinez ME, Nathanson KL, Neuhausen SL, O'Brien KM, Olson JE, Palmer JR, Patel AV, Ruddy KJ, Sandler DP, Teras LR, Weinberg CR, Weitzel JN, Winham SJ, Yadav S, Yao S, Zirpoli G, Janatova M, Kleibl Z, Kleiblova P, Soukupova J, CZECANCA consortium, Zhao Q, Devereux L, James PA, Campbell IG, Nguyen-Dumont T, Dowty JG, Andrieu N, Lesueur F, Stoppa-Lyonnet D, GENESIS, Hoya M, Radice P, Sørensen CS, Peterlongo P. +117 moreeuropepmc +1 more sourceUsing gene-environment interactions to explore pathways for colorectal cancer risk. [PDF]
EBioMedicineBouras E, Yu R, Kim AE, Markozannes G, Murphy N, Albanes D, Anderson LN, Barry EL, Berndt SI, Bishop DT, Brenner H, Burnett-Hartman A, Campbell PT, Carreras-Torres R, Chan AT, Cheng I, Devall MA, Diez-Obrero V, Dimou N, Drew DA, Gruber SB, Gsur A, Hoffmeister M, Hsu L, Huyghe JR, Kawaguchi E, Keku TO, Kundaje A, Küry S, Le Marchand L, Lewinger JP, Li L, Lynch BM, Moreno V, Morrison JL, Newton CC, Obón-Santacana M, Palmer JR, Papadimitriou N, Pellatt AJ, Peoples AR, Pharoah PDP, Platz EA, Qu C, Ruiz-Narvaez E, Mendez JS, Schoen RE, Stern MC, Thomas CE, Tian Y, Um CY, Visvanathan K, Vodicka P, Vymetalkova V, White E, Wolk A, Woods MO, Wu AH, Gunter MJ, Gauderman WJ, Peters U, Evangelou M, Tsilidis KK. +62 moreeuropepmc +1 more sourceFGF14 repeat length and mosaic interruptions: modifiers of spinocerebellar ataxia 27B? [PDF]
BrainLaß J, Thomsen M, Borsche M, Lüth T, Prietzsche JC, Schaake S, Milovanović A, Macpherson H, Gustavsson EK, Saffie Awad P, Dragašević-Mišković N, Laabs BH, König IR, Westenberger A, Pearson CE, Brüggemann N, Klein C, Trinh J. +17 moreeuropepmc +1 more source
