Results 31 to 40 of about 1,310,067 (208)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Genocidas ir Rezistencija, 2011 This article describes the political events in Lithuania under German occupation in the spring of 1943, when, thanks to the unified resistance of Lithuanian society, the establishment of an SS legion was foiled and the German occupiers started ...
Rimantas Zizas
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Merops apiaster burrow (re)-occupation
, 2015 10 years of individually followed burrows and their (re)-occupation patterns in a German population of the European bee-eater Merops ...
Hans-Valentin Bastian (3257178) +7 more
core +1 more source
Kaunas Hard Labour Prison in the Years of Nazi Occupation (1941–1944)
Genocidas ir Rezistencija, 2009 At the beginning of the war and Nazi occupation, with the efforts of the recreating Lithuanian administration, the system of prisons and forced labour camps, which operated in the years of the Republic of Lithuania and Soviet occupation, was renewed.
Arūnas Bubnys
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Kelmė and Vaiguva Jewish Communities and Their Perishing in 1941
Genocidas ir Rezistencija, 2011 It is believed that Jews settled in Kelmė in the 15th century and in Vaiguva in the 18th century. In 1897, 2,710 of the 3,914 residents of Kelmė were Jews.
Stanislovas Buchaveckas
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Genocidas ir Rezistencija, 2015 The article is dedicated to the annihilation of the Jewish communities of Palanga and Darbėnai rural areas of Kretinga County in summer and autumn 1941.
Alfredas Rukšėnas
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source