Results 101 to 110 of about 1,022,480 (312)

Fibrillar Elastomeric Micropatterns Create Tunable Adhesion Even to Rough Surfaces [PDF]

, 2016
Acknowledgements V.B., N.K.G., and E.A. contributed with conception and experimental design. V.B. performed the experiments. V.B., R.H., A.G., and R.M.M. carried out analysis and interpretation of data. V.B., R.H., A.G., and E.A. wrote the manuscript.
Arzt, Eduard, Barreau, Viktoriia, Ghatak, Animangsu, Guimard, Nathalie K., Hensel, René, Mcmeeking, Robert M.   +5 more
core   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Real-Time Loss Tools: Open-Source Software for Time- and State-Dependent Seismic Damage and Loss Calculations – Features and Application to the 2023 Türkiye-Syria Sequence

Seismica
During a seismic sequence, the action of each earthquake has the potential to damage and weaken exposed structures, causing their fragility to change, and increasing their likelihood of being further damaged by subsequent earthquakes.
Cecilia Nievas, Helen Crowley, Graeme Weatherill, Fabrice Cotton   +3 more
doaj   +1 more source

Combined 3D characterization of porous zeolites by STEM and FIB tomography [PDF]

, 2014
German Research Foundation Priority Program 1570German Research Foundation Cluster of Excellence EXC 315 “Engineering of Advanced ...
Beltrán, Ana M., Machoke, Albert Gonche, Przybilla, Thomas, Schwieger, Wilhelm, Spiecker, Erdmann, Winter, B.   +5 more
core  

The Phylogenetic Likelihood Library [PDF]

, 2015
[Abstract] We introduce the Phylogenetic Likelihood Library (PLL), a highly optimized application programming interface for developing likelihood-based phylogenetic inference and postanalysis software.
Aberer, Andre J., Darriba, Diego, Flouri, Tomas, Haeseler, Arndt von, Izquierdo-Carrasco, F., Minh, B.Q., Nguyen, Lam-Tung, Stamatakis, Alexandros   +7 more
core   +4 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phosholipase C gamma 1 and protein kinase C pathways [PDF]

, 2016
This work was supported by the German Research Foundation DFG (SFB 850/B6) and by the Fritz-Thyssen foundation (Az.10.14.2.150) to C.-W.F and the Medical Research Council (MR/L010402/1) to D.P ...
A Murthy, A Sääf, A Toker, AA Długosz, BM Lichtenberger, CA Strott, CP Blobel, CW Franzke, CW Franzke, DC Blaydon, DC Blaydon, E Candi, E Candi, E Proksch, E Ueda, EM Hur, F Spörl, G Adhikary, H Wakita, HR Seo, JJ Peschon, JM Haugh, K Chanprapaph, K Chida, K Nishi, L Eckhart, LJ Russell, M Jost, M Kashiwagi, M Ohba, M Piepkorn, M Pigors, M Raghunath, M Sibilia, MA Brooke, MF Denning, MF Denning, MJ Kim, MJ Wieduwilt, MR Schneider, NJ Reynolds, P Campbell, P Gierschik, P Tsukerman, PJ Miettinen, PT La Celle, RA Black, S John, S Kawabe, S Pastore, S Tholen, SS Tibudan, U Sahin, V Mitev, X Cheng, Z Xie   +55 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Receptor-Like Kinase SERK3/BAK1 Is Required for Basal Resistance against the Late Blight Pathogen Phytophthora infestans in Nicotiana benthamiana [PDF]

, 2015
BACKGROUND The filamentous oomycete plant pathogen Phytophthora infestans causes late blight, an economically important disease, on members of the nightshade family (Solanaceae), such as the crop plants potato and tomato.
Chaparro-Garcia, Angela, Coffey, Michael D., Findlay, Kim, Gimenez-Ibanez, Selena, Kamoun, Sophien, Rathjen, John P., Schornack, Sebastian, Wilkinson, Rachael C., Zipfel, Cyril   +8 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source