Results 101 to 110 of about 215,077 (307)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Real-Time Loss Tools: Open-Source Software for Time- and State-Dependent Seismic Damage and Loss Calculations – Features and Application to the 2023 Türkiye-Syria Sequence

Seismica
During a seismic sequence, the action of each earthquake has the potential to damage and weaken exposed structures, causing their fragility to change, and increasing their likelihood of being further damaged by subsequent earthquakes.
Cecilia Nievas, Helen Crowley, Graeme Weatherill, Fabrice Cotton   +3 more
doaj   +1 more source

Additional file 2 of Effects of temperature gradient on functional fruit traits: an elevation-for-temperature approach

Supplementary Material 2.Dr. Arthur Pfungst-Stiftung German Research Foundation (DFG– FZT ) German Centre for Integrative Biodiversity Research (iDiv).Peer ...
Nevo, Omer, Gómez-Devia, Laura
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The association between feelings of loneliness and the number of social relationships in depression: a cross-sectional study of German adults

BMC Psychiatry
Background Depression is a common psychiatric disorder that is associated with both feelings of loneliness and withdrawal from social relationships. However, clinical experience suggests that feelings of loneliness are an integral part of depressive ...
Valeria Koppert, Andreas Czaplicki, Ulrich Hegerl   +2 more
doaj   +1 more source

A Compact Wideband Monopole Antenna using Single Open Loop Resonator for Wireless Communication Applications

, 2018
A novel single layer, microstrip line fed compact wideband monopole antenna using open loop resonator has been designed and analyzed. The proposed antenna occupies a compact size of only 30 36.5 1.6 mm3.
Boutejdar, Ahmed; German Research Foundation (DFG), Challal, Mouloud; University M’Hamed Bougara of Boumerdes, Bennani, Saad S.; University Sidi Mohamed Ben Abdellah Fès, Sarkar, P. P; Univrsity of Kalyani, Salamin, Mohammad A.; Electrical, Telecommunications and, Electronics Engineer, Hani, Soumia El; Mohammed V University in Rabat, Das, Sudipta; Department of Electronics and Communication Engineering   +6 more
core   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Integration Through Separation - The Role of Lateral Membrane Segregation in Nutrient Uptake [PDF]

, 2019
Nutrient transporters are prominent and ubiquitous components of the plasma membrane in all cell types. Their expression and regulation are tightly linked to the cells' needs.
Wedlich Soeldner, Roland, Busto, Jon V., Wedlich Söldner, Roland, Busto Gamero, Jon V.   +3 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source