Results 231 to 240 of about 1,018,571 (313)

Molecular architecture of human dermal sleeping nociceptors. [PDF]

Cell
Körner J, Howard D, Solinski HJ, Mancilla Moreno M, Haag N, Fiebig A, Maxion A, Bhuiyan SA, Toklucu I, Bott RA, Sankaranarayanan I, Tavares-Ferreira D, Shiers S, Inturi NN, Eberhardt E, Ernst L, Bonaguro L, Schulte-Schrepping J, Beyer MD, Stiehl T, Renthal W, Kurth I, Tigerholm J, Serra J, Price TJ, Schmelz M, Namer B, Tripathy S, Lampert A.   +28 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Multicentre prospective non-interventional study protocol for evaluating surgical strategies for Colorectal Resections and Postoperative Quality of Life in Retroperitoneal Sarcoma Patients Across German-Speaking Sarcoma Centres (COLOSARC-Q). [PDF]

BMJ Open
Hettler M, Scharpf KR, Eich A, Albertsmeier M, Duprée A, Hetjens S, Harbrücker M, Menge F, Betzler A, Hohenberger P, Jakob J.   +10 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Caspase-activation powers anti-Desmoglein 3-induced acantholysis in human epidermis. [PDF]

Cell Death Discov
Schmidt MF, Feoktistova MA, Panayotova-Dimitrova D, Buhl EM, Boor P, Ruhl T, Waschke J, Tikkanen R, Röcken M, Baron JM, Yazdi AS.   +10 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Endothelial ZBTB16: a molecular shield against cardiac aging. [PDF]

Eur Heart J
Stilz KA, Leonard VE, Rodriguez Morales D, Glaser SF, Larcher V, Ruz Jurado M, Malacarne PF, Manickam N, Tombor LS, Abplanalp WT, Panthel J, Kujundzic H, Fischer A, Schmitz K, Müller OJ, Hille S, Kupatt C, Bozoglu T, Sami H, Ogris M, Procida-Kowalski T, Bartkuhn M, John D, Yekelchyk M, Schmachtel T, Rieger M, Pham MD, Krishnan J, Günther S, Brandes RP, Braun T, Zeiher AM, Wagner JUG, Dimmeler S.   +33 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Validation of the moral foundations questionnaire-2 (MFQ-2) in Germany: Psychometric properties and associations with political ideology, religiosity, and personality. [PDF]

PLoS One
Musa NS, Müller SM, Hopp FR.
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source