Results 211 to 220 of about 1,022,480 (312)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Time-bin encoded quantum key distribution over 120 km with a telecom quantum dot source. [PDF]

Light Sci Appl
Wang J, Hanel J, Jiang Z, Joos R, Jetter M, Rugeramigabo EP, Portalupi SL, Michler P, Cao XY, Yin HL, Shan L, Yang J, Zopf M, Ding F.   +13 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Comparison Between Browser- and App-Based Versions of a Program for Self-Management of Mild to Moderate Depression: Log Data Analysis of a Convenience Sample.

JMIR Mhealth Uhealth
Scholze K, Allenhof C, Hegerl U.
europepmc   +1 more source

Semantic alignment of the German Human Genome-Phenome Archive metadata model in Europe's genomics field. [PDF]

Sci Data
Mauer K, Iyappan A, Parker S, Sürün B, Tremper G, Menges P, Kuchenbecker L, Kirli K, Schultze JL, Nahnsen S, Ulas T, GHGA Consortium.   +11 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Early distant progression in adult Histone-3 K27-altered diffuse midline gliomas. [PDF]

J Neurooncol
Grassl N, Suwala AK, Kessler T, Bunse L, Mildenberger I, Breckwoldt MO, Ratliff M, Brehmer S, Herold-Mende C, Etminan N, Wick W, Sahm F, Platten M, Sahm K.   +13 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Mobile Apps and Websites With Breastfeeding-Related Content in Germany: Cross-Sectional and Evaluation Study. [PDF]

JMIR Pediatr Parent
Ziebart M, Jäger V, Theurich MA, Koletzko BV.   +3 more
europepmc   +1 more source