Results 41 to 50 of about 5,183 (253)

Convergences and Divergences of the Law of Non- Compliance of the German Civil Code with the Principles of European Law of Contracts and Other International Texts

open access: yesDerecho PUCP, 2018
The aim of the proposed investigation is to revise critically the German reform of the obligations (2002), establishing its main implications and relevance within the process of unification of European Law obligations and contracts, and especially of the
Rodrigo Barcia Lehmann   +1 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From Kosovo Rush to Mass Atrocities’ Hush. German Debates since Unification

open access: yesComparative Southeast European Studies, 2022
Germany’s involvement in the Kosovo War marked its first active participation in combat operations since the Second World War. For many observers at the time, the intervention represented a fundamental policy shift in the West, and in Germany in ...
Hering Robin, Stahl Bernhard
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

"On the 'Burden' of German Unification The Economic Consequences of Messrs. Waigel and Tietmeyer" [PDF]

open access: yes
This paper investigates the causes of western Germany's remarkably poor performance since 1992. The paper challenges the view that the poor record of the nineties, particularly the marked deterioration in public finances since unification, might be ...
Jorg Bibow
core   +2 more sources

What Influences the Rate of Entry into Motherhood of Women Enrolled in Full-Time Education? A Difference-in-Differences Analysis of the Effect of the German Unification [PDF]

open access: yesStudies of Transition States and Societies, 2013
The purpose of this paper is to study the entry into motherhood of women in full-time education in East and West Germany before and after German unification.
Gwendolin J. Blossfeld
doaj  

La sfera pubblica tedesca nell’Europa della crisi

open access: yesQuaderni di Sociologia, 2015
Contrary to the long pro-European tradition of post-war Germany, a silent repositioning of German governments and public opinion on EU topics has taken place in recent years.
Walter Privitera
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

On the ‘burden’ of German unification

open access: yesPSL Quarterly Review, 2003
This paper investigates the causes of western Germany's remarkably poor performance since 1992. It challenges the view that Germany's poor economic record and marked deterioration in public finances since unification might be largely attributable to that
Jorg Bibow
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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