Results 41 to 50 of about 1,458,179 (339)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Learning from the Germans? History and Memory in German and European Discourses of Integration

open access: yesPORTAL: Journal of Multidisciplinary International Studies, 2007
History and memory appear to be increasingly important to discussions of European values and identity, as exemplified by references to ‘bitter experiences’ and ‘divided pasts’ in the draft EU constitution. The article takes recent suggestions that Europe
Andrew Beattie
doaj   +3 more sources

Einheit [PDF]

open access: yesRechtsgeschichte - Legal History, 2005
The unification of the German states in 1990 was accompanied by a major transfer of law and a remarkable transfer of legal staff. The legislation which followed in the train of the unification was extraordinary in its dimensions.
Manfred Aschke
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Convergences and Divergences of the Law of Non- Compliance of the German Civil Code with the Principles of European Law of Contracts and Other International Texts

open access: yesDerecho PUCP, 2018
The aim of the proposed investigation is to revise critically the German reform of the obligations (2002), establishing its main implications and relevance within the process of unification of European Law obligations and contracts, and especially of the
Rodrigo Barcia Lehmann   +1 more
doaj   +1 more source

Women, identity and employment in East Germany [PDF]

open access: yes, 2003
This book chapter was reproduced with the kind permission of Continuum books.This book chapter discusses Marxist feminism and female employment in the GDR, current attitudes to employment amongst East German women, and pre-unification versus post ...
Wagener, Debbie
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Emotional and emotive language: modal particles and tags in unified Berlin [PDF]

open access: yes, 2005
This paper endeavours to show the relationship between emotion and language, in particular with respect to the use of modal particles in German. Modal particles have long been considered insignificant fillers without a specific function and as such, not ...
Abraham   +35 more
core   +1 more source

German Unification: What Have We Learned from Multi-Country Models?

open access: yesSocial Science Research Network, 1996
This study reports on early simulations of the effects of German unification using three different rational-expectations multi-country models. Despite significant differences in their structures and in the implementations of the unification shock, the ...
Joseph E. Gagnon   +3 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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