Results 51 to 60 of about 1,057,217 (295)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
La sfera pubblica tedesca nell’Europa della crisi
Quaderni di Sociologia, 2015 Contrary to the long pro-European tradition of post-war Germany, a silent repositioning of German governments and public opinion on EU topics has taken place in recent years.
Walter Privitera
doaj +1 more source
Rechtsgeschichte - Legal History, 2003 Western European legal historiography deplores the 19th century as the age of destruction of the Romanrooted ius commune by national codes. In reality the French code civil, the Austrian ABGB and the German Pandectist jurisprudence effected rather a ...
Tomasz Giaro
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
German unification in perspective [PDF]
Intereconomics, 1992 When German unification took place in 1990, the government was optimistic that the process of closing the economic gap between the two Germanies would be a brief one. However, economic unification has turned out to be more costly and much more complex than anticipated.
openaire +2 more sources
German unification: A progress report [PDF]
In the five years after unification, efforts to bring up the eastern part of Germany to the level of the western one have made considerable progress. Eastern Germany's growth is moving towards the double digits, just like growth in the Pacific Rim region.
Schmidt, Klaus-Dieter
core
"Hazardous Waste Management Policy in the European Union: Case of Germany and Unification Illustrates Need to Consider Principle of Subsidiarity" [PDF]
, 1995 Environmental legislation and especially that relating to hazardous waste management remains an area in which careful consideration has to be given to the nature of the problem before legislation is harmonized and standardized.
Simonsson, Eva.
core