Results 71 to 80 of about 1,458,179 (339)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Binnenwanderungen seit der deutschen Einigung
Raumforschung und Raumordnung, 2004 With the opening of the inner-German boundaries in 1989, the unification of Germany and the following upheavals in numerous sectors of life in East Germany, the general conditions for spatial mobility in Germany were redefined.
Claus Schlömer
doaj +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
The burden of German unification: a generational accounting approach [PDF]
An assessment of the generational stance of postunification German fiscal policy and an estimate of the burden of unification-related fiscal measures on West German generations, finding that future generations will bear much larger lifetime net tax ...
Bernd Raffelhuschen +2 more
core
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Politikon, 2003 The EU enlargement is inside the historical tendency of continental Europe to be dominated by a German-Russian axis. The “creation of Europe” has been the German continuation of WW1 and WW2 in other ways.
Roberto Scaruffi
doaj +1 more source
[30 years of German unification: achievements and remaining differences in mortality trends by age and cause of death]. [PDF]
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 2021 Grigoriev P +4 more
europepmc +1 more source
International effects of German unification [PDF]
, 2008 The merger of the two German states brings together countries with divergent economic systems, different trade orientations and a rift in terms of wealth.
Welfens, Paul J. J.
core +1 more source