Results 71 to 80 of about 1,403,653 (384)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Binnenwanderungen seit der deutschen Einigung
Raumforschung und Raumordnung, 2004 With the opening of the inner-German boundaries in 1989, the unification of Germany and the following upheavals in numerous sectors of life in East Germany, the general conditions for spatial mobility in Germany were redefined.
Claus Schlömer
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Politikon, 2003 The EU enlargement is inside the historical tendency of continental Europe to be dominated by a German-Russian axis. The “creation of Europe” has been the German continuation of WW1 and WW2 in other ways.
Roberto Scaruffi
doaj +1 more source
[30 years of German unification: achievements and remaining differences in mortality trends by age and cause of death]. [PDF]
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 2021 Grigoriev P +4 more
europepmc +1 more source
The burden of German unification: a generational accounting approach [PDF]
An assessment of the generational stance of postunification German fiscal policy and an estimate of the burden of unification-related fiscal measures on West German generations, finding that future generations will bear much larger lifetime net tax ...
Bernd Raffelhuschen +2 more
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