Results 91 to 100 of about 327,377 (313)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

„In der englischen Sprache zu schreiben war eigentlich eine Zumutung für mich“

open access: yesRecherches Germaniques, 2019
George Tabori (1914-2007), playwriter, stage director and Georg Büchner Prize recipient in 1992, is considered to be one of the most emblematic figures of German theater from the 1980s and 1990s.
Dirk Weissmann
doaj   +1 more source

Reading the geographies of post-war British film culture through the reception of French film [PDF]

open access: yes, 2013
This paper examines the ways in which British specialist film culture anticipated and received the resumed supply of French films at the end of the Second World War.
Acland Charles   +16 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Writing war, writing memory: the representation of the recent past and the construction of cultural memory in contemporary Bosnian prose [PDF]

open access: yes, 2010
Focusing on the work of Miljenko Jergović, Nenad Veličković, Alma Lazarevska, and Saša Stanišić, this paper examines how the representation of the recent past intertwines with the construction of collective memory in contemporary Bosnian prose.
Vervaet, Stijn
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Some Reflections on the Teaching of Military History in Canada [PDF]

open access: yes, 2012
Military History occupies a somewhat tenuous position in the curricula of Canadian universities. It is most often regarded as a kind of marginal enterprise to be offered by a faculty member who has some side-interest in these matters as a relief from the
Vogel, Robert
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

"What, in fact, is a book!" (to the problem of implicit study of the theory of literature in the middle link of the school)

open access: yesФилологический класс, 2004
The author of the article tells about the experience of working with schoolchildren while studying the novel “Endless Book” by M. Ende.
doaj  

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