Results 121 to 130 of about 328,568 (309)
Вестник Кемеровского государственного университета, 2015 The paper deals with the alienation of the former wartime allies from each other in the early post-war period with the example of the first (and last) All-German Writers‘ Congress in Berlin in October 1947.
B. Bonwetsch
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
The The Mystery of the German Writer’s Vessel:
Revista Brasileira de Estudos da PresençaThis article investigates the politics of the image and montage in the literature and filmmaking as an experimentation with an ethical bet on research in Human Sciences. In the light of Walter Benjamin’s concept of montage, as well as DidiHuberman’s analysis of image as taking a position, it problematizes the insurmountable distance between the subject
openaire +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
لحظه حماسی, داستایوفسکی به روایت اشتفان تسوایگ
Naqd-i Zabān va Adabīyyāt-i Khārijī, 2016 Fyodor Dostoevsky is undoubtedly one of the greatest writers and thinkers of the world. The influence of German philosophy and literature is clear and evident in Dostoevsky works. But looking on the surface of his writings and looking deeper on his works,
رائد فریدزاده
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HumanitiesThis article explores the complex struggle for identity in the works of three prominent Moravia-born Prague German writers of the early twentieth century: Ernst Weiß, Hermann Ungar, and Ludwig Winder.
Michal Smrkovsky
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source