Results 81 to 90 of about 167,769 (338)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Direct Detection of sub-GeV Dark Matter with Semiconductor Targets

, 2016
Dark matter in the sub-GeV mass range is a theoretically motivated but largely unexplored paradigm. Such light masses are out of reach for conventional nuclear recoil direct detection experiments, but may be detected through the small ionization signals ...
Essig, Rouven, Fernandez-Serra, Marivi, Mardon, Jeremy, Soto, Adrian, Volansky, Tomer, Yu, Tien-Tien   +5 more
core   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

A Review of germanium environmental distribution, migration and accumulation [PDF]

, 2020
А. В. Соболев, Олександр Іванович Соболєв, B. V. Gutyj, Б. В. Гутий, Світлана Іванівна Соболєва, Світлана Василівна Соболєва, Oleksandr Borshch, Oleksandr Borshch, Ігор Михайлович Кушнір, Ігор Михайлович Кушнір, Роман Анатолійович Петришак, Роман Анатолійович Петришак, A. Naumyuk, Олександр Сергійович Наумюк, V. F. Kushnir, Василь Ігорович Кушнір, Ольга Йосипівна Петришак, Ольга Йосипівна Петришак, Mykola Zhelavsky, Микола Миколайович Желавський, Василь Богданович Тодорюк, Василь Богданович Тодорюк, H. V. Klym, Галина Володимирівна Сус, Natalia Levkivska, Наталія Дмитрівна Левківська, Andrey Vysotskij, Андрій Олексійович Висоцький, Nadiya Magrelo, Н. В. Магрело   +29 more
openalex   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Germanium recovery from zinc calcines using a hydrometallurgical procedure

Revista de Metalurgia
In the final stage of zinc calcines processing, zinc is recovered by zinc electrowinning. However, the presence of germanium in the electrolyte seriously affects the current density in the electrowinning step. Since germanium is a critical and strategic
Francisco José Alguacil , Manuel Alonso, Luis J. Lozano-Blanco, José Ignacio Robla   +3 more
doaj   +1 more source

Optical properties of Germanium nanoparticles synthesized by pulsed laser ablation in acetone

Frontiers in Physics, 2014
Germanium (Ge) nanoparticles (NPs) are synthesized by means of pulsed laser ablation of bulk germanium target immersed in acetone with ns laser pulses at different pulse energies.
Saikiran eVadavalli, Sreeramulu eValligatla, Sreeramulu eValligatla, Sreeramulu eValligatla, Bharati eNeelamraju, Mudasir H Dar, Alessandro eChiasera, Maurizio eFerrari, Narayana Rao Desai   +8 more
doaj   +1 more source

Muonium as a hydrogen analogue in silicon and germanium; quantum effects and hyperfine parameters

, 1999
We report a first-principles theoretical study of hyperfine interactions, zero-point effects and defect energetics of muonium and hydrogen impurities in silicon and germanium.
A. R. Porter, B. D. Patterson, C. G. Van de Walle, C. G. Van de Walle, C. G. Van de Walle, C. Pisani, D. M. Ceperley, E. R. Cohen, H. J. Monkhorst, J. P. Perdew, J. P. Perdew, K. J. Chang, M. C. R. Symons, M. Casarin, M. D. Towler, M. F. Guest, P. Hohenberg, R. G. Parr, R. H. Luchsinger, R. J. Needs, R. L. Lichti, R. P. Feynman, R. Ramírez, S. F. Boys, S. F. J. Cox, S. F. J. Cox, S. R. Kreitzman, S. Vogel, T. A. Claxton, T. Miyake, W. Kohn   +30 more
core   +1 more source