Results 111 to 120 of about 49,142 (306)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Jews and Germans in Eastern Europe [PDF]

open access: yes, 2018
"For many centuries Jews and Germans were economically and culturally of significant importance in East-Central and Eastern Europe. Since both groups had a very similar background of origin (Central Europe) and spoke languages which are related to each ...

core  

Traces of German settlement in the modern-day cultural landscape of the Carpathians

open access: yesMiscellanea Geographica: Regional Studies on Development
Although German settlement in the Carpathians and their forelands declined to a minimum after World War II and again with the fall of Communism, its traces in the cultural landscape are still visible.
Jordan Peter
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Germans in Germany's Ethnic Neighborhoods [PDF]

open access: yes
In contrast to most research on the effects on residents of living in an ethnic neighborhood, this paper explores how living within an ethnic neighborhood affects members of the dominant ethnic group - in this case Germans - rather than the minorities ...
Anita I. Drever
core  

Folklore of the Pennsylvania Germans [PDF]

open access: yes, 1915
A typed thesis paper completed at Franklin and Marshall College entitled, Folklore of the Pennsylvania Germans , by Isaac Shirk Simons, dated May 20, 1915.
Simons, Isaac Shirk
core  

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