Results 41 to 50 of about 1,223,353 (236)

Should Mama or Papa Work? Variations in Attitudes towards Parental Employment by Country of Origin and Child Age

open access: yesComparative Population Studies, 2023
Employment among mothers has been rising in recent decades, although mothers of young children often work fewer hours than other women do. Parallel to this trend, approval of maternal employment has increased, albeit not evenly across groups.
Ludovica Gambaro   +3 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

Security Cooperation of Great Britain and West Germany in the Years 1979–1985

open access: yesHistoria i Polityka, 2017
The article considers the main directions and forms of cooperation between Great Britain and West Germany in the security policy in 1979–1985. Selecting the time frame of research is based on the important international events which had a significant ...
Iryna Kaviaka
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Don’t Smoke, Take Drink in Moderation, Do Walk a Lot and Do Not Gorge Yourself beyond Your Satiation: Health Education by Television in West Germany from the 1960s to the 1980s

open access: yesVIEW Journal of European Television History and Culture, 2020
This article discusses health education through television in West Germany, with a focus on nutrition and physical activity. Public health initiatives on television contributed to the fitness boom of the late 1960s and 1970s that aimed to counterbalance ...
Vollberg, Susanne
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Cross-Sectional Study on Influenza Vaccination, Germany, 1999–2000

open access: yesEmerging Infectious Diseases, 2002
To assess influenza vaccination coverage in Germany, we conducted a nationwide telephone survey in November 1999 in adults (>18 yrs) using random-digit dialing. Overall, 23% of 1,190 survey participants reported having been vaccinated (adjusted 18%) with
Sybille Rehmet   +4 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

General self-efficacy in East and West Germany: A comparison of two German representative cohorts in 2014 and 2022What this study adds:Implications for Policy and Practice:

open access: yesPublic Health in Practice
Objectives: Empirical evidence increasingly highlights the importance of general self-efficacy (GEF) in preventing disease and promoting quality of life.
Anna C. Reinwarth   +5 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

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