Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci +6 more
wiley +1 more source
Lissner – the Reflection of Sorge
RUDN Journal of World History, 2014 The biography of Ivar Lissner is presented – a person, who worked in the Far-Eastern region in 30–40 th of the XX century and actually repeated the fate of the Soviet Military Intelligence member Richard Sorge. Lissners destiny reflected
A Grigor'evich Fesyun
doaj
Comparative Anatomy of Vertebrates . Adapted from the German of Dr. Robert Wiedersheim, Professor of Anatomy in Freiburg, by W. N. Parker, Professor of Zoology in the University of Wales. Royal octavo, pp. 576, 372 figures. Macmillan and Co., 1907. Third edition, founded on the sixth German edition (pp. 800, 416 figures). [PDF]
, 1908 Burt G. Wilder
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Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
An Introduction to Electricity . By Bruno Kolbe. Being a translation of the second German edition (1904-5) by Joseph Skellon. Cloth, 8Svo, pp. viii + 430. Philadelphia, J. B. Lippincott Co.; London, Kegan. Paul, Trench Triibner & Co. 1908. [PDF]
, 1909 S. J. Barnett
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TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Arthurian Legends or the Hebrew-German Rhymed Version of the Legend of King Arthur [PDF]
, 1914 L. A. Willoughby, Lazare Landau
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Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source