Results 121 to 130 of about 5,819,085 (193)

Correction: Deficiency in nucleoside diphosphate kinase B leads to endothelial activation of the hexosamine biosynthesis pathway and cardiac dysfunction. [PDF]

Cardiovasc Diabetol
Shao F, Wieland J, Wang Y, Keles M, Meng Z, Lomada S, Qin M, Leiss V, Martin-Garrido A, Fuhrmann M, Qiu Y, Trogisch FA, Vettel C, Heineke J, Feng Y.   +14 more
europepmc   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Correction: The sarcoma ring trial: a case-based analysis of inter-center agreement across 21 German-speaking sarcoma centers. [PDF]

J Cancer Res Clin Oncol
Roohani S, Handtke J, Hummedah K, Albertsmeier M, Andreou D, Apostolidis L, Augustin M, Bauer S, Billner M, Bösch F, Deinzer CKW, Deventer N, Duprée A, Eckert F, Engel L, Fechner K, Fritzsche H, Gaidzik V, Ghani S, Grützmann R, Guder WK, Hamacher R, Hecker JS, Hendricks A, Hillmann A, Houben P, Hübner G, Ivanyi P, Jentsch C, Jordan M, Kappl P, Kaths M, Kessler T, Kirchberg J, Knebel C, Krempien R, Lehner B, Lenze U, Lindner LH, Lörsch AM, Maguire N, Müller S, Piso P, Potkrajcic V, Reichardt P, Richter S, Schewe S, Schiffmann LM, Scholten F, Striefler JK, Schwarzbach M, Seidensaal K, Semrau S, Szkandera J, Szuszies CJ, Timmermann B, Tuchscherer A, Wiegering A, Winkelmann MT, Kaul D, Jakob J.   +60 more
europepmc   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Author Correction: A multicenter study of asymmetric and symmetric dimethylarginine as predictors of mortality risk in hospitalized COVID-19 patients. [PDF]

Sci Rep
Hannemann J, Zink A, Mileva Y, Balfanz P, Dahl E, Volland S, Illig T, Schwedhelm E, Kurth F, Stege A, Aepfelbacher M, Hofmann A, Böger R.   +12 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Thermal Desorption and Extraction Coupled With Gas Chromatography and Mass Spectrometry for the Quantification of Polystyrene Nanoplastic in Pak Choi. [PDF]

Rapid Commun Mass Spectrom
Zytowski E, Baldermann S.
europepmc   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Mental Health and Experiences of Anti-Semitism in 2nd and 3rd Offspring Generation of Holocaust Survivors From Israel, Germany, and the USA. [PDF]

Int J Psychol
Nesterko Y, Specht F, Stammel N, Nohr L, Böttche M.   +4 more
europepmc   +1 more source