Results 121 to 130 of about 2,724,689 (240)

Treatment of acute myeloid leukemia (AML): Recent results and new directions [PDF]

International Journal of Hematology-Oncology and Stem Cell Research, 2004
Thomas Büchner University of Münster, Germany   +1 more
doaj  

Correction to: Tiprelestat for Treatment of Hospitalized COVID-19: Results of the Double-Blind Randomized Placebo-Controlled COMCOVID Trial. [PDF]

Adv Ther
Bergs I, Budweiser S, Henneicke-von Zepelin HH, Kelm H, Bollmann T, Tebbe JJ, Sorichter S, Lüth S, Walterspacher S, Wege H, Wiedow O, Dreher M.   +11 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Social inequalities in cancer in Germany: a call to action. [PDF]

J Cancer Res Clin Oncol
Sibert NT, Wellbrock M, Bedir A, Grundmann N, Herrmann M, Hoebel J, Jansen L, Popova V, Schwettmann L, Arndt V, Brand T, Gude AC, Hoe C, Hübner J, Lückemeyer M, Mons U, Dalton SO, Voigtländer S, Erdmann F.   +18 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Correction: Strong constitutive NF-κB signaling in B cells drives SLL/CLL-like lymphomagenesis and overcomes microenvironmental dependencies. [PDF]

Leukemia
Soberón V, Osswald L, Moore A, Sosnowska D, Swinerd G, Chen J, Baygün S, Diehl C, Seyhan G, Kraus L, Gölling V, Trapp R, O'Neill TJ, Bortoluzzi S, Kovacs D, Ammon T, Singroul P, Hubarzhevska Y, Öllinger R, Mueller S, Baranov O, Giansanti P, Gillhuber F, Grath S, Weigert O, Rosenwald A, Sasaki Y, Rajewsky K, Steiger K, Bassermann F, Rad R, Krappmann D, Ringshausen I, Schmidt-Supprian M.   +33 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Polygenic scores for executive functioning as predictors of performance improvements after repeated testing in major psychiatric disorders. [PDF]

Sci Rep
Navarro-Flores A, Heilbronner M, Rafiee H, Wendel B, Papiol S, Adorjan K, Budde M, Oraki Kohshour M, Schulte EC, Reich-Erkelenz D, Senner F, Anghelescu IG, Arolt V, Baune BT, Dannlowski U, Dietrich DE, Fallgatter AJ, Figge C, Lang FU, Juckel G, Konrad C, Reimer J, Reininghaus EZ, Schmauß M, Schmitt A, Spitzer C, Wiltfang J, Zimmermann J, Falkai P, Schulze TG, Heilbronner U.   +30 more
europepmc   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source