Results 141 to 150 of about 5,819,085 (193)

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Sex Differences in the In-Hospital Mortality of Patients with Acute Myocardial Infarction: A Cross-Sectional Study in 36 Hospitals Across Germany. [PDF]

Medicina (Kaunas)
Kostev K, Kaur N, Kluge S, Konrad M, Sedighi J, Lüdde M.   +5 more
europepmc   +1 more source

Enhanced discovery of bacterial laccase‐like multicopper oxidase through computer simulation and metagenomic analysis of industrial wastewater

FEBS Open Bio, EarlyView.
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui, Ariel Kushmaro, Hana Barak, Anja Poehlein, Rolf Daniel, Hans‐Jürgen Mägert   +5 more
wiley   +1 more source

Evaluation of Baseline Characteristics and Therapeutic Management Strategies in Metastatic Cervical Cancer in Germany: A Multicentric Retrospective Longitudinal Observational Study: A Quality Assurance Initiative of the AGO-Study Group and AGO-OK Uterus.

Geburtshilfe Frauenheilkd
Denschlag D, Czogalla B, Heitz F, Kerkmann M, Fangmann LC, Klecker PH, Stuebs FA, Wölber L, Radosa J, Lodde PC, Seitz S, George C, Mach P, Fink A, Bokhua D, deGregorio N, Lampe B, Hemptenmacher F, Friebe V, Fleisch M, Wimberger P, Jaeger A, Schnelzer A, Mittelstadt S, Ratiu D, Eichbaum M, Haus A, Kalder M, Ataseven B, Schröder W, Bronger H, Kosse J, Ulrich UA, Elser G, Harter P.   +34 more
europepmc   +1 more source

Correction: Preferences of patients with high-risk HR+/HER2- breast cancer for adjuvant endocrine treatment: an adaptive choice-based conjoint analysis study from Germany. [PDF]

Breast Cancer Res Treat
Wöckel A, Park-Simon TW, Korfel A, Raab K, Tesch H.   +4 more
europepmc   +1 more source

Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins

FEBS Open Bio, EarlyView.
With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet, Julia Bartoli, Atakan Kabtan, Chloé M. Piras, Audrey C. Tempier, Eric Cascales, Julie P. Viala   +6 more
wiley   +1 more source

Correction: Impact of simulated patient-based communication training vs. real patientbased communication training on empathetic behaviour in undergraduate students- a prospective evaluation study. [PDF]

BMC Med Educ
Britz V, Sterz J, Koch Y, Schreckenbach T, Stefanescu MC, Zinßer U, Verboket RD, Sommer K, Ruesseler M.   +8 more
europepmc   +1 more source

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

FEBS Open Bio, EarlyView.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Claudia Valentina Popa, Simona Ghenea, Ileana Cornelia Farcasanu   +4 more
wiley   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

FEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel, Rachel Brown, Alexa Rabeling, Mubeen Goolam   +3 more
wiley   +1 more source

Application of IVDr NMR spectroscopy to stratify Parkinson's disease with absolute quantitation of blood serum metabolites and lipoproteins. [PDF]

Sci Rep
Berezhnoy G, Bae G, Wüst L, Schulte C, Cannet C, Wurster I, Zimmermann M, Jäck A, Spruth EJ, Hellmann-Regen J, Roeske S, Pürner D, Glanz W, Maass F, Hufschmidt F, Kilimann I, Dinter E, Kimmich O, Gamez A, Levin J, Priller J, Peters O, Wagner M, Storch A, Lingor P, Düzel E, van Riesen C, Wüllner U, Teipel S, Falkenburger B, Bähr M, Zerr I, Petzold GC, Spottke A, Rizzu P, Brosseron F, Schäfer H, Gasser T, Trautwein C.   +38 more
europepmc   +1 more source