Results 151 to 160 of about 2,808,091 (266)

Genetic Testing by Age at Onset in Parkinson Disease.

JAMA Neurol
Balck A, Vollstedt EJ, Westenberger A, Lange LM, Trinh J, Kasten M, Lohmann K, Brüggemann N, Trenkwalder C, Mollenhauer B, Alcalay R, Galvelis KG, Beck JC, Bauer P, Klein C, König IR, Global Parkinson’s Genetics Program (GP2), the ROPAD Study Group, and the PDGENEration Study.   +18 more
europepmc   +1 more source

Correction: Furin as target for suppression of mosquito-borne viruses. [PDF]

Virol J
Centurión A, Omokungbe B, Oberpaul M, Dersch L, Stiehler S, Chambers C, Lechner M, Lüddecke T, Vilcinskas A, Steinmetzer T, Hardes K.   +10 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Incidence and remission of endometriosis in Germany based on prevalence data from 35 million patients from the statutory health insurance. [PDF]

BMC Womens Health
Schütte Saem M, Voß S, Pytlik T, Schiermeier S, Brinks R, Ickstadt K.   +5 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Frailty among older adults in Germany: regional variation across NAKO study centers. [PDF]

Int J Equity Health
König M, Rach S, Mikolajczyk R, Schöttker B, Mons U, Amthor M, Völzke H, Meinke-Franze C, Harth V, Obi N, Schulze MB, Thorand B, Greiser KH, Leitzmann M, Herrmann A, Lieb W, Kiekert J, Keil T, Krist L, Schmidt B, Heise JK, Nimptsch K, Pischon T, Ittermann T.   +23 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Breastfeeding at discharge or transfer from the maternity hospital: results from the German Perinatal Statistics 2021. [PDF]

Int Breastfeed J
Brettschneider AK, Abou-Dakn M, Längler A, Schlune A, Ensenauer R.   +4 more
europepmc   +1 more source

Germany (Federal Republic of Germany)

, 2023
Detterbeck, Klaus, Griffiths, Ann, Chattopadhyay, Rupak, Light, John, Stieren, Carl   +4 more
openaire   +1 more source