Results 171 to 180 of about 6,907,799 (304)

Both Smallpox and Mpox Vaccine Reduce Mpox Disease Severity and Symptoms. [PDF]

Open Forum Infect Dis
Hoffmann C, Breitschwerdt S, Bickel M, Appelhans C, Jessen HK, Franz S, Kolarikal H, Krznaric I, Lenz J, Schuler C, Baumgarten A, Schultheiß T, Esser S, Biller M, Stein LD, Bender M, Rausch M, Baumann R, Haars U, Dialer I, Khaykin P, Roider J, Wyen C, Spinner CD, Wagner L, Schäfer G, Boesecke C.   +26 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Baby Boomers in Germany: a secondary data analysis of demographics, regional disparities, healthcare utilization, and mortality. [PDF]

BMC Public Health
Kuehnl A, Schmid VJ, Olm M, Weber W.
europepmc   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Correction: The influence of structured reporting on the accuracy of head and neck sonographies. [PDF]

Sci Rep
Weimer JM, Künzel J, Raczeck C, Hodeib M, Koppen T, Weimer L, Levi A, Rink M, Becker S, Ernst BP.   +9 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Correction: Rise and dine: unraveling breakfast habits among tenth graders - a cross-sectional study among 646 students in the City of Witten, Germany (GeWIT study). [PDF]

BMC Public Health
Mohamed MSA, Dianti NR, Heye AL, Völkel K, Tillmann J, Klassen O, Wiesheu P, Weckbecker K, Münster E.   +8 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Effect of High-Dose Oral Insulin in Children With Stage 1 Type 1 Diabetes: The Fr1da Insulin Intervention Randomized Controlled Trial. [PDF]

Diabetes Care
Ziegler AG, Albeer A, Arnolds S, Assfalg R, Bunk M, Daniel C, Hofelich A, Jacobsen S, Kick K, Knoop J, Kohls M, Kordonouri O, Matzke C, Pfirrmann M, Ramminger C, Sarcletti K, Scholz M, Schütte-Borkovec K, Serr I, Weigelt M, Weiss A, Winkler C, Bonifacio E, Achenbach P.   +23 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source