Results 201 to 210 of about 6,907,799 (304)

Between guidelines and reality: expert neurologists' perspectives on structural resources for ALS care in Germany. [PDF]

Neurol Res Pract
Linse K, Lulé D, Schöberl F, Reilich P, Ilse B, Metelmann M, Eickhoff C, Bublitz S, Lorenzl S, Boentert M, Petri S, Rödiger A, Smesny U, Wolf J, Weyen U, Zeller D, Dorst J, Maier A, Meyer T, Lingor P, Hermann A, Regensburger M, Großkreutz J, Runge C, Lapp HS, Freigang M, Vidovic M, Aust E, Weber C, Günther R.   +29 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Lockdown COVID‑19: a stress test revealing more about the mental health system than psychopathology-A comparative analysis between Austria, Germany, and Italy. [PDF]

Front Public Health
de Bertoldi F, Finos L, Roux P, Gaspari D, Di Pauli J, Ullrich H, Benedetti N, Bizzarri J, Neugebauer J, Peter Plum P, Nitti M, Conca A.   +11 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Author Correction: From short-term uncertainties to long-term certainties in the future evolution of the Antarctic Ice Sheet. [PDF]

Nat Commun
Coulon V, Klose AK, Edwards T, Turner F, Pattyn F, Winkelmann R.   +5 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Correction: Treatment of Patients with Early Breast Cancer: 19th St. Gallen International Breast Cancer Consensus Discussed against the Background of German Treatment Recommendations. [PDF]

Geburtshilfe Frauenheilkd
Untch M, Banys-Paluchowski M, Brucker SY, Denkert C, Fasching PA, Haidinger R, Harbeck N, Janni W, Krug D, Loibl S, Lüftner D, Michel L, Schumacher-Wulf E, Solbach C, Würstlein R, Huober J, Ditsch N.   +16 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Analysis of Bond Strength of Bioceramic Sealer Following Irrigation with Chlorhexidine. [PDF]

Iran Endod J
Costa LG, Saldanha JM, da Silva-Filho JE, Aguiar BA, de Almeida Gomes F, Gurgel-Filho ED.   +5 more
europepmc   +1 more source