Results 281 to 290 of about 8,371,157 (388)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Correction: Sex-specific outcomes in myocardial infarction: a dual-cohort analysis using clinical and real-world data. [PDF]

Clin Res Cardiol
Krefting J, Graesser C, Novacek S, Voll F, Moggio A, Krueger N, Friess C, Schwab M, Offenborn F, Trenkwalder T, Kufner S, Xhepa E, Joner M, Cassese S, Schunkert H, Ndrepepa G, Kastrati A, von Scheidt M, Kessler T, Sager HB.   +19 more
europepmc   +1 more source

Acute Q fever infection in Thuringia, Germany, after burial of roe deer fawn cadavers (Capreolus capreolus): a case report

, 2015
Benjamin T. Schleenvoigt, Lisa D. Sprague, Katja Mertens‐Scholz, Udo Moog, Gernot Schmoock, Günter Wolf, M. Neumann, Mathias W. Pletz, Heinrich Neubauer   +8 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Concept and feasibility of privacy-preserving record linkage of cancer registry data and claims data in Germany: results from the DigiNet study on stage IV non-small cell lung cancer. [PDF]

J Cancer Res Clin Oncol
Kästner A, Hampf C, Naumann P, Fiedler-Lacombe L, Kron A, Spier A, Simic D, Eilers L, Graw A, Bartholomäus S, Stang A, Reil D, Kirschner-Schwabe R, Selig JI, Wulff J, Dröge P, Ruhnke T, Günster C, Nußbaum U, Marschall U, Mohnke J, Hebbelmann A, Lührig U, Rasokat A, Mildenberger V, Stock S, Kron F, Wolf J, Bialke M, Stahl D, van den Berg N, Hoffmann W.   +31 more
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Median urinary iodine concentration reflected sufficient iodine supply in neonates from Northeast Germany in 2005–2006

, 2018
Till Ittermann, Henry Völzke, Anne Krey, Thomas Remer, Matthias Heckmann, Anja Lange, Axel Krämer, Harald Below   +7 more
openalex   +2 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Accreditation and qualification of primary care teaching practices in Germany - a nationwide online survey of universities. [PDF]

GMS J Med Educ
Gehrke-Beck S, Kitte I, Streitlein-Böhme I, Deutsch T, Demmer I, Gornostayeva M, Jendyk R.   +6 more
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source