Results 241 to 250 of about 49,637 (286)
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Annual Review of Immunology, 1994
Germinal centers develop in the B cell follicles of secondary lymphoid tissues during T cell-dependent (TD) antibody responses. The B cells that give rise to germinal centers initially have to be activated outside follicles, in the T cell-rich zones in association with interdigitating cells and T cell help.
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Germinal centers develop in the B cell follicles of secondary lymphoid tissues during T cell-dependent (TD) antibody responses. The B cells that give rise to germinal centers initially have to be activated outside follicles, in the T cell-rich zones in association with interdigitating cells and T cell help.
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Immunological Reviews, 1997
Summary: Using a set of surface markers Including igD and CD38, human tonsillar B cells were classified into discrete subpopulations. Molecular and functional analysis allowed us to identify: i) two sets of naive B cells (Bml and Bm2); ii) germinal center founder cells (Bm2′); iii) an obscure population of germinal center B cells, displaying a high ...
Liu, Yong-Jun, Arpin, Christophe
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Summary: Using a set of surface markers Including igD and CD38, human tonsillar B cells were classified into discrete subpopulations. Molecular and functional analysis allowed us to identify: i) two sets of naive B cells (Bml and Bm2); ii) germinal center founder cells (Bm2′); iii) an obscure population of germinal center B cells, displaying a high ...
Liu, Yong-Jun, Arpin, Christophe
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Current Opinion in Hematology, 2001
The germinal center reaction is one critical outcome of helper T-cell-dependent antigen-specific B-cell responses. Germinal center reactions are the culmination of an orchestrated series of intercellular information exchanges discussed here as the serial synapsis model of adaptive immunity.
L J, McHeyzer-Williams +2 more
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The germinal center reaction is one critical outcome of helper T-cell-dependent antigen-specific B-cell responses. Germinal center reactions are the culmination of an orchestrated series of intercellular information exchanges discussed here as the serial synapsis model of adaptive immunity.
L J, McHeyzer-Williams +2 more
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Monocytes asphyxiate germinal centers
Immunity, 2022Some bacteria and parasites, such as Salmonella, actively disrupt germinal centers and elicit only low affinity antibodies, but the mechanisms by which microbes alter these responses is poorly understood. In this issue of Immunity, Biram et al. (2022) uncover a mechanism by which Salmonella recruits Sca-1+ monocytes to germinal centers and impairs ...
Yuke, He, Carola G, Vinuesa
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2020
Germinal centers (GCs) are transient microstructures formed within the follicles of secondary lymphoid tissues in response to certain types of immunization and foreign pathogens. A mature GC comprises two functionally distinct compartments, a dark zone (DZ) and a light zone (LZ).
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Germinal centers (GCs) are transient microstructures formed within the follicles of secondary lymphoid tissues in response to certain types of immunization and foreign pathogens. A mature GC comprises two functionally distinct compartments, a dark zone (DZ) and a light zone (LZ).
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Invasion of the germinal centers
Cell, 2023After vaccination or infection, long-lived germinal centers can produce antibodies with high affinity and specificity against pathogens. In this issue of Cell, de Carvalho et al. and Hägglöf et al. show that naive B cells can invade germinal centers, replacing B cells that entered early and changing features of antibody production.
Daniel P, Maurer, Aaron G, Schmidt
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Journal of Allergy and Clinical Immunology, 2010
The germinal center (GC) reaction is the basis of T-dependent humoral immunity against foreign pathogens and the ultimate expression of the adaptive immune response. GCs represent a unique collaboration between proliferating antigen-specific B cells, T follicular helper cells, and the specialized follicular dendritic cells that constitutively occupy ...
Dominique, Gatto, Robert, Brink
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The germinal center (GC) reaction is the basis of T-dependent humoral immunity against foreign pathogens and the ultimate expression of the adaptive immune response. GCs represent a unique collaboration between proliferating antigen-specific B cells, T follicular helper cells, and the specialized follicular dendritic cells that constitutively occupy ...
Dominique, Gatto, Robert, Brink
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Getting toGether in Germinal centers
Science Immunology, 2021Ggt5 cleaves the ligand of P2RY8 in lymph node follicles and generates a gradient that supports B cell confinement to germinal centers.
Liat Stoler-Barak, Ziv Shulman
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Germinal centers develop oligoclonally
European Journal of Immunology, 1987AbstractAs part of our studies into the role of germinal centers, we investigated whether each de novo generated germinal center (GC) develops from one single GC precursor cell (GCPC, monoclonal development), a few GCPC (oligoclonal development) or from many GCPC (polyclonal development).
Kroese, FGM +3 more
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Critical Reviews in Immunology, 2004
The germinal center reaction is the foundation of T-cell-dependent humoral responses. Antigen-specific B cells recruited into germinal centers undergo a complex cellular program that allows for extensive expansion, isotype switching, somatic hypermutation, and differentiation into antibody-forming cells and memory cells.
Kristy L, Wolniak +2 more
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The germinal center reaction is the foundation of T-cell-dependent humoral responses. Antigen-specific B cells recruited into germinal centers undergo a complex cellular program that allows for extensive expansion, isotype switching, somatic hypermutation, and differentiation into antibody-forming cells and memory cells.
Kristy L, Wolniak +2 more
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