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Germline Epimutation in Humans
Pharmacogenomics, 2008Epigenetic modifications provide all multicellular organisms with a system of gene regulation that allows clonally heritable yet reversible alterations in gene transcription. Errors in this complex system can give rise to abnormal gene silencing, termed 'epimutation'; importantly, this can occur in the absence of any underlying genetic defect ...
Jennifer E, Cropley +2 more
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Testicular germline stem cells
Nature Reviews Urology, 2010Stem cells have the ability to both differentiate into other mature cell types and maintain an undifferentiated state by self-renewal. These unique properties form the basis for stem cell use in organ replacement and tissue regeneration in clinical medicine. Currently, embryonic stem cells are the best-studied stem cell type.
Kehkooi, Kee +2 more
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Non-Human Germline Interventions
The American Journal of Bioethics, 2020Cwik (2020) has written an excellent paper. His proposal that we analyze human germline genetic interventions in terms of their targets, goals, possible outcomes, and mechanisms seems sensible and ...
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Germline Editing: Editors Cautionary.
La Clinica terapeutica, 2018This communication is regarding the recent editing of the genome of the human embryo with CRISPR/Cas9 which generated a debate amongst the biological scientists around the world. Editing human germline genes may act as godsend in some serious genetic and other disorders as the genes related to these disorders can be replaced effectively. The scientists
K, Krishan +4 more
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Germline stem cell homeostasis
2019In many species, germline stem cells (GSCs) function to sustain gametogenesis throughout the life of organismal life span. As the source of gametes, the only cell type that can pass the genetic information to the next generation, GSCs play a fundamental role in maximizing the quantity of gametes that animals produce, while ensuring their highest ...
Jonathan O, Nelson +2 more
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2006
Abstract The issue of germline mosaicism has generated a great deal of uncertainty in the provision of genetic risks over the past 10–15 years. Previously, this was not perceived to be a major concern. Rare reports of siblings with conditions such as campomelic dysplasia, severe osteogenesis imperfecta, and pseudoachondroplasia, born to ...
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Abstract The issue of germline mosaicism has generated a great deal of uncertainty in the provision of genetic risks over the past 10–15 years. Previously, this was not perceived to be a major concern. Rare reports of siblings with conditions such as campomelic dysplasia, severe osteogenesis imperfecta, and pseudoachondroplasia, born to ...
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Inherited Aneuploidy: Germline Mosaicism
Cytogenetic and Genome Research, 2011Germline mosaicism has been thought to be a rare cause of aneuploidy in the human population. Recent evidence from cytological and population studies suggests otherwise. Approximately 5% of young couples with a Down syndrome child show evidence of germinal mosaicism. Molecular cytogenetic analysis of oocytes has proved germinal or gonadal mosaicism for
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Germline Transgenesis in Ciona
2018Transgenesis is an indispensable method for elucidating the cellular and molecular mechanisms underlying biological phenomena. In Ciona, transgenic lines that have a transgene insertion in their genomes have been created. The transgenic lines are valuable because they express reporter genes in a nonmosaic manner.
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