Results 171 to 180 of about 13,351 (224)

Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma–pancreatic carcinoma–prone families [PDF]

, 2001
Henry T. Lynch, Randall E. Brand, David Hogg, Carolyn Deters, Ramon M. Fusaro, Jane F. Lynch, Ling Liu, Joseph A. Knezetic, Norman J. Lassam, Michael Goggins, Scott E. Kern   +10 more
openalex   +1 more source

Predisposing conditions in patients with small intestinal adenocarcinomas in the Netherlands: A 20‐year nationwide cohort study

International Journal of Cancer, EarlyView.
What's New? Although small intestinal adenocarcinoma (SIA) shares certain similarities with colorectal cancer, its etiology and predisposing conditions presumably are distinct. Due to the rarity of SIA, however, detailed information on predisposing factors is lacking.
Jasmijn D. G. Linssen, Pascale J. M. Schafrat, Tim R. de Back, Felice N. van Erning, Monique E. van Leerdam, Evelien Dekker, Louis Vermeulen, Ignace H. J. T. de Hingh, Dirkje W. Sommeijer   +8 more
wiley   +1 more source

Germline E-cadherin gene mutations [PDF]

, 2001
Yun Shin Chun, Noralane M. Lindor, Thomas C. Smyrk, Bret T. Petersen, Lawrence J. Burgart, Parry Guilford, John H. Donohue   +6 more
openalex   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Mutational germline analysis of hMSH2 and hMLH1 genes in early onset colorectal cancer patients

, 2000
M. Montera
openalex   +1 more source

The TESTBREAST journey: Revisiting the importance of early detection by frequent screening of women at high risk of breast cancer

International Journal of Cancer, EarlyView.
What's New? Women who are at high risk of breast cancer (BC), either because of a BRCA1/2 mutation or family history, require more aggressive screening. Here, the authors report on the clinical characteristics of the high‐risk women who developed BC during the TESTBREAST study. Of the 1108 participants, 124 (16.5%) developed breast cancer. Their median
Layla Andour, Sophie C. Hagenaars, Kiki Vangangelt, Janneke Aalberts, Valerie Rebattu, Dorien M. A. Berends van der Meer, Elma Meershoek‐Klein Kranenbarg, Katja N. Gaarenstroom, Christi J. van Asperen, Rob A. E. M. Tollenaar, Wilma E. Mesker, on behalf of the TESTBREAST study team, J. Aalberts, T. M. A. Berends‐van der Meer, S. C. Hagenaars, L. Andour, W.E. Mesker, R. A. E. M Tollenaar, W. M. Meershoek‐Klein Kranenbarg, K. N. Gaarenstroom, C. M. R. Haekens, K. B. M. I. Keymeulen, J. Remmelzwaal, M. Piek‐den Hartog, E. J. T. Rutgers, C. Drukker, C. Lemstra, A. Prozee, J. de Vries, A. Stam, C. Bandel, I. Meijer, A. E. Dassen, S. Makineli, E. E. van Oers‐Hazelzet, A. J. Witkamp, K. E. Schenk, W. van der Eijk, M. B. E. Menke‐Pluijmers, J. de Droog‐Laane, B. A. Kortmann   +40 more
wiley   +1 more source

Germline and somatic mutation analyses in the DNA mismatch repair geneMLH3: Evidence for somatic mutation in colorectal cancers [PDF]

, 2001
Steven M. Lipkin, Victoria Wang, Dan L. Stoler, Garth R. Anderson, Ilan R. Kirsch, Don W. Hadley, Henry T. Lynch, Francis S. Collins   +7 more
openalex   +1 more source

Comprehensive genetic and epigenetic characterization of Lynch‐like syndrome patients

International Journal of Cancer, EarlyView.
What's New? Lynch‐like syndrome is associated with development of colorectal cancer (CRC) with microsatellite instability and loss of expression of certain mismatch repair (MMR) genes, similar to Lynch syndrome, but unlike Lynch syndrome, the genetic cause of Lynch‐like syndrome (LLS) remains unknown.
Francesca Pirini, Luciano Calzari, Gianluca Tedaldi, Michela Tebaldi, Valentina Zampiga, Ilaria Cangini, Rita Danesi, Mila Ravegnani, Valentina Arcangeli, Alessandro Passardi, Elisabetta Petracci, Sara Bravaccini, Giorgia Marisi, Alessandra Viel, Daniela Barana, Monica Pedroni, Luca Roncucci, Daniele Calistri, Davide Gentilini   +18 more
wiley   +1 more source

Germline Mutation of Dihydropyrimidine Dehydrogenese Gene among a Japanese Population in Relation to Toxicity to 5‐Fluorouracil [PDF]

, 2001
Kensei Yamaguchi, Yalçın Aral, Yuzo Kanda, Kiwamu Akagi   +3 more
openalex   +1 more source

Limited association between HRR gene alterations and HRD in molecular tumor board cancer samples: Who should be tested for HRD?

International Journal of Cancer, EarlyView.
What's New? Currently, no published data on homologous recombination deficiency (HRD) testing in the setting of molecular tumor boards exist. This study in a cohort of 237 patients encompassing 24 different tumor entities assessed by a molecular tumor board shows that inactivating alterations of BRCA1/2 are not always associated with an elevated ...
Christoph Schubart, Lars Tögel, Maria Giulia Carta, Philip Hetzner, Lina Helbig, Charlotte Zaglas, Maria Ziegler, Robert Stöhr, Annett Hölsken, Juliane Hoyer, Fulvia Ferrazzi, Clemens Neufert, Sebastian Lettmaier, Marianne Pavel, Henriette Golcher, Sarina K. Mueller, Florian Fuchs, Carla E. Schulmeyer, Matthias W. Beckmann, Bernd Wullich, Abbas Agaimy, Andre Reis, Arndt Hartmann, Norbert Meidenbauer, Silvia Spoerl, Florian Haller, Evgeny A. Moskalev   +26 more
wiley   +1 more source