Results 161 to 170 of about 123,315 (302)
Head &Neck, EarlyView.ABSTRACT Objective To provide a comprehensive review of the biological rationale, clinical evidence, and practical perioperative management of immunotherapy for the head and neck surgeon. Summary Background Data Standard treatment for resectable head and neck squamous cell carcinoma (HNSCC) has reached a survival plateau, with over 50% of patients ...
Nicholas Brian Shannon, Bruce Ashford
wiley +1 more source
The many faces of an aging germline: reduced germline mutation rate at reproductive peak
Germline mutations are the ultimate source of genetic diversity, and germline mutation rate is central to evolutionary biology. However, while germline mutations primarily arise during DNA replication in the parental germline and should accumulate with ...
Chen, Hwei-Yen
core +1 more source
What sets the mutation rate of a cell type in an animal species?
PLoS BiologyGermline mutation rates per generation are strikingly similar across animals, despite vast differences in life histories. Analogously, in at least one somatic cell type, mutation burdens at the end of lifespans are comparable across mammals.
Marc de Manuel +3 more
doaj +1 more source
Developing New Tools for Detecting Germline Mutation Induction in Mice
, 2012 A Thesis Submitted to the Faculty of Graduate Studies and Research In Partial Fulfillment of the Requirements for the Degree of Master of Science in Biology, University of Regina.
Beal, Marc Andrew
core
International Journal of Cancer, EarlyView.Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer +11 more
wiley +1 more source
Living at genetic risk: The patient experience of Lynch syndrome
International Journal of Cancer, EarlyView.Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents +2 more
wiley +1 more source
International Journal of Cancer, EarlyView.Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia +4 more
wiley +1 more source
Association of Childhood Acute Leukemia With Autoimmune Diseases
International Journal of Cancer, EarlyView.A possible link exists between various pediatric autoimmune diseases (AIDs) and increased risk of childhood leukemia. Although immune dysregulation is a key feature of these conditions, the connection between them remains unclear. In this study, using cancer registry data in Finland, the authors examined associations between AIDs and childhood acute ...
Ida Pellikka +4 more
wiley +1 more source
Study onBRCA1/2 andATMgermline mutations in the Chinese prostate cancer patients
Zhongguo aizheng zazhi, 2018 Background and purpose: Pathogenic germline mutations in BRCA1/2 and ATM are significantly associated with risk and progression of prostate cancer.
吴俊龙, 顾伟杰
doaj
International Journal of Cancer, EarlyView.The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg +9 more
wiley +1 more source