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Multiple colorectal adenomas in Lynch syndrome

Frontiers in Oncology, 2022
BackgroundLynch syndrome has not traditionally been considered to have a high colorectal adenoma burden. However, with increasing adenoma detection rates in the general population, the incidence of adenoma detection in Lynch syndrome may also be ...
Ayushi Jain, Maryam Alimirah, Heather Hampel, Rachel Pearlman, Jianing Ma, Jing Peng, Matthew F. Kalady, Matthew F. Kalady, Peter P. Stanich   +8 more
doaj   +1 more source

Pediatric manifestations of Lynch Syndrome: A single center experience

Journal of Pediatric Surgery Case Reports, 2022
Lynch syndrome is an autosomal dominant condition caused by a heterozygous variation in one of the DNA mismatch repair (MMR) genes that pre-disposes individuals to early onset colorectal cancers and other malignancies.
Taleen A. MacArthur, Laura J. Ongie, Brendan C. Lanpher, Michael B. Ishitani   +3 more
doaj   +1 more source

Early onset of colorectal cancer in a 13-year-old girl with Lynch syndrome [PDF]

Korean Journal of Pediatrics, 2016
Lynch syndrome is the most common inherited colon cancer syndrome. Patients with Lynch syndrome develop a range of cancers including colorectal cancer (CRC) and carry a mutation on one of the mismatched repair (MMR) genes.
Do Hee Ahn, Jung Hee Rho, Hann Tchah, In-Sang Jeon   +3 more
doaj   +1 more source

The prevalence of lynch syndrome (DNA mismatch repair protein deficiency) in patients with primary localized prostate cancer using immunohistochemistry screening

Hereditary Cancer in Clinical Practice, 2023
Background Prostate cancer is one of the most heritable human cancers. Lynch syndrome is an autosomal dominant inheritance caused by germline mutations in DNA mismatch repair (MMR) genes, which are also associated with an increased incidence of prostate ...
Suguru Oka, Shinji Urakami, Kiichi Hagiwara, Michikata Hayashida, Kazushige Sakaguchi, Yuji Miura, Naoko Inoshita, Masami Arai   +7 more
doaj   +1 more source

Updates in gynecologic care for individuals with lynch syndrome

Frontiers in Oncology, 2023
Lynch syndrome is an autosomal dominant hereditary cancer syndrome caused by germline pathogenic variants (PVs) in DNA mismatch repair genes (MLH1, MSH2, PMS2, MSH6) or the EPCAM gene. It is estimated to affect 1 in 300 individuals and confers a lifetime
Kaylee A. Underkofler, Kari L. Ring
doaj   +1 more source

What is currently known about endometrial cancer in Lynch syndrome? - review

Journal of Education, Health and Sport, 2019
Introduction: About 5% of endometrial cancer cases can be genetic and inherited. Lynch syndrome, also called hereditary non-polyposis colorectal cancer (HNPCC), is an autosomal dominant syndrome.
Agnieszka Kwiatkowska, Dominika Krawczyk, Krzysztof Kułak, Sylwester Makuch, Klaudia Sapko   +4 more
doaj   +3 more sources

Case report: Undifferentiated sarcoma with multiple tumors involved in Lynch syndrome: Unexpected favorable outcome to sintilimab combined with chemotherapy

Frontiers in Oncology, 2022
BackgroundPatients with Lynch syndrome are at an increased risk of developing simultaneous or metachronous tumors, while sarcomas have been occasionally reported.
Jiaying Liu, Xiaona Chang, Guixiang Xiao, Jingmin Zhong, Bo Huang, Jiwei Zhang, Beibei Gao, Gang Peng, Xiu Nie   +8 more
doaj   +1 more source

Same Gene Mutation But Variable Phenotypes in 2 Families With Lynch Syndrome: Two Case Reports and Review of Genotype-Phenotype Correlation

Clinical Medicine Insights: Case Reports, 2018
Lynch syndrome is an autosomal dominant syndrome that can be subdivided into Lynch syndrome I, or site-specific colonic cancer, and Lynch syndrome II, or extracolonic cancers, particularly carcinomas of the stomach, endometrium, biliary and pancreatic ...
Raffaella Liccardo, Marina De Rosa, Francesca Duraturo   +2 more
doaj   +1 more source

Molecular subtype classification of urothelial carcinoma in Lynch syndrome

Molecular Oncology, 2018
Lynch syndrome confers an increased risk for urothelial carcinoma (UC). Molecular subtypes may be relevant to prognosis and therapeutic possibilities, but have to date not been defined in Lynch syndrome‐associated urothelial cancer. We aimed to provide a
Christina Therkildsen, Pontus Eriksson, Mattias Höglund, Mats Jönsson, Gottfrid Sjödahl, Mef Nilbert, Fredrik Liedberg   +6 more
doaj   +1 more source

IDH1 mutated low grade astrocytoma occurring in MSH2 mutated Lynch syndrome family

Human Pathology: Case Reports, 2016
Lynch syndrome (LS) is an autosomal dominant tumour predisposition syndrome caused by a germline mutation in one of the DNA mismatch repair (MMR) genes.Patients with these mutations have an increased risk of brain tumours, the vast majority of which are ...
Alaa Alkhotani, Ingrid Ambus, Lea Velsher, Corwyn Rowsell, Julia Keith   +4 more
doaj   +1 more source