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Hereditary Cancer in Clinical Practice, 2008 It is estimated that a highly penetrant genetic predisposition is the cause of 10-20% of all colorectal cancers (CRC) [1-5]. Among the well known syndromes of inherited predisposition to tumours manifesting with CRC, syndromes showing a Mendelian pattern of inheritance include: hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome ...
Józef Kładny, Jan Lubiński
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Hereditary Nonpolyposis Colon Cancer (Lynch Syndrome): An Emerging Public Health Concern [PDF]
Health Science ReportsBackground Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is an autosomal dominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes that confer increased lifetime risks for colorectal, endometrial,
Md Mohiuddin
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Pediatric manifestations of Lynch Syndrome: A single center experience
Journal of Pediatric Surgery Case Reports, 2022 Lynch syndrome is an autosomal dominant condition caused by a heterozygous variation in one of the DNA mismatch repair (MMR) genes that pre-disposes individuals to early onset colorectal cancers and other malignancies.
Taleen A. MacArthur +3 more
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Multiple colorectal adenomas in Lynch syndrome
Frontiers in Oncology, 2022 BackgroundLynch syndrome has not traditionally been considered to have a high colorectal adenoma burden. However, with increasing adenoma detection rates in the general population, the incidence of adenoma detection in Lynch syndrome may also be ...
Ayushi Jain +8 more
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Identifying Lynch syndrome [PDF]
International Journal of Cancer, 2009 In the March 1 issue of Int J Cancer an editorial concludes that “Therefore, this population-based study has provided evidence that molecular screening and genetic testing all colorectal tumors diagnosed before age 50 years will identify most Lynch syndrome cases”.1 The study referred to was published in the same issue of the journal.2 We strongly ...
Albert, de la Chapelle +2 more
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Early onset of colorectal cancer in a 13-year-old girl with Lynch syndrome [PDF]
Korean Journal of Pediatrics, 2016 Lynch syndrome is the most common inherited colon cancer syndrome. Patients with Lynch syndrome develop a range of cancers including colorectal cancer (CRC) and carry a mutation on one of the mismatched repair (MMR) genes.
Do Hee Ahn +3 more
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Hereditary Cancer in Clinical Practice, 2023 Background Prostate cancer is one of the most heritable human cancers. Lynch syndrome is an autosomal dominant inheritance caused by germline mutations in DNA mismatch repair (MMR) genes, which are also associated with an increased incidence of prostate ...
Suguru Oka +7 more
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Updates in gynecologic care for individuals with lynch syndrome
Frontiers in Oncology, 2023 Lynch syndrome is an autosomal dominant hereditary cancer syndrome caused by germline pathogenic variants (PVs) in DNA mismatch repair genes (MLH1, MSH2, PMS2, MSH6) or the EPCAM gene. It is estimated to affect 1 in 300 individuals and confers a lifetime
Kaylee A. Underkofler, Kari L. Ring
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A model-based assessment of the cost-utility of strategies to identify Lynch syndrome in early-onset colorectal cancer patients. [PDF]
, 2015 This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.BACKGROUND: Lynch syndrome is an autosomal dominant cancer predisposition syndrome caused by mutations in the DNA ...
Coelho, H +7 more
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A case of squamous cell carcinoma of the skin due to the molecularly confirmed Lynch Syndrome [PDF]
, 2015 Patients with Lynch Syndrome are at high risk for developing a variety of cancers including cancers of the colon or rectum, small bowel, stomach, uterus, renal pelvis, ureter, biliary tract, ovaries, brain and pancreas (N Engl J Med 348: 919-32, 2003 ...
Sorscher, Steven
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