Results 1 to 10 of about 7,924 (110)

A Rare Case of Seminoma in an Elderly Patient With Suspected Lynch Syndrome. [PDF]

Clin Case Rep
ABSTRACT Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer, is caused by mutations in the mismatch repair genes and confers genetic predisposition to colorectal and other cancers. Germ cell tumors, the majority of which are seminomas, usually arise sporadically and predominantly occur in younger patients; their association ...
Kamandi M, Boozari M, Soltani E, Soltani S.   +3 more
europepmc   +2 more sources

High Grade Dysplastic Rectal Adenoma in a Young Patient With Café-Au-Lait Spots: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Colorectal cancer screening guidelines typically focus on familial history and age‐related risk factors, yet Café‐au‐lait macules could serve as early indicators for tailored surveillance protocols. This case underscores the importance of considering extracolonic manifestations in young patients presenting with colorectal symptoms.
Hamdan A, Zeid RA, Khalil J, Karam K, Fiani E.   +4 more
europepmc   +2 more sources

Hereditary Nonpolyposis Colon Cancer (Lynch Syndrome): An Emerging Public Health Concern. [PDF]

Health Sci Rep
ABSTRACT Background Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is an autosomal dominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes that confer increased lifetime risks for colorectal, endometrial, and other cancers.
Mohiuddin M.
europepmc   +2 more sources

Clinical Discovery and Molecular Analysis of Two Novel MSH2 Gene Mutations (p.Ala771Gly and p.Val797Gly) in Saudi Colorectal Cancer Patients: Potential Implications for Tumorigenesis. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Colorectal cancer (CRC) is a serious global health problem, ranking first in men and third in women among all cancers worldwide. The genetic basis for CRC remains unclear in most cases; therefore, the present study aimed to investigate the molecular genetic basis of CRC and correlate it with disease outcomes.
Rasool M, Haque A, Alharthi M, Ali T, Karim S, Mira LS, Al-Abbasi F, Aljiffry M, Ghunaim M, Sibiany A, Pushparaj PN.   +10 more
europepmc   +2 more sources

The difficult diagnosis of a patient presenting with a Krukenberg tumor and Lynch syndrome: a case report [PDF]

Journal of Medical Case Reports
Background Krukenberg tumors are a rare condition representing only 1% of ovarian tumors. Lynch syndrome only results in ovarian tumors in 1% of cases. Both diagnoses can be challenging, leading to delayed treatment.
Amaury Poque, Pierre Peyrafort, Julie Delvallée   +2 more
doaj   +2 more sources

Syndrome in question [PDF]

Anais Brasileiros de Dermatologia, 2015
Muir-Torre syndrome is a rare genodermatosis characterized by the occurrence of at least one sebaceous tumor associated with visceral neoplasia, but with no predisposing factors.
Catharina Maria Freire de Lucena Pousa, Fernanda Guedes Lavorato, Fernanda Valente Rehfeldt, Danielle Mann, Maria de Fátima Gonçalves Scotelaro Alves   +4 more
doaj   +1 more source

Lynch syndrome: An unusal case of familial cancer unearthed

Indian Journal of Pathology and Microbiology, 2022
Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) is a type of inherited cancer syndrome with a genetic predisposition to different types of cancer.
Subhra Dhar, Ashraf U Mannan, J Jaya Singh, Sandipan Dhar, Swetalina Pradhan   +4 more
doaj   +1 more source

Hereditary colorectal cancer syndromes [PDF]

Iranian Journal of Colorectal Research, 2020
Context: In recent decades there has been an increase in hereditary colorectal cancer cases in people under 50 years of age. Several studies revealed similar pathologies with both molecular and clinical variations about hereditary colorectal neoplasms ...
Fernanda Rivera, Yuliana Mendoza, Heriberto Medina   +2 more
doaj   +1 more source

Predictive factors based on the health belief model on cancer screening behaviour in first degree relatives of patients with Lynch syndrome-associated colorectal cancer

International Journal of Nursing Sciences, 2023
Objectives: This study aimed to investigate colorectal cancer-related knowledge, health beliefs, and screening behaviour in first-degree relatives (FDRs) of patients with Lynch syndrome-associated colorectal cancer (CRC) and explore the predictive ...
Jiaojiao Gu, Shumin Jia, Huaxiang Chao, Tinglan Chen, Xiaodan Wu   +4 more
doaj   +1 more source

Distress, anxiety, and depression in persons with hereditary cancer syndromes: Results from a nationwide cross‐sectional study in Germany

Cancer Medicine, 2023
Background Persons with hereditary cancer syndromes (carriers) have a higher risk of developing cancer early. They are confronted with decisions regarding prophylactic surgeries, communication within their families, and childbearing.
Anna Maria Kastner, Josefine Fischer‐Jacobs, Jan Brederecke, Andrea Hahne, Tanja Zimmermann   +4 more
doaj   +1 more source