Results 21 to 30 of about 7,899 (110)
Journal of Coloproctology, 2020 Introduction: Colorectal carcinoma is the third most prevalent neoplasm in the world, and the second cause of death by cancer. The most part of these neoplasms are sporadic by somatic mutations, but around 15% are hereditary, such as Lynch syndrome or ...
Maria Beatriz de Matos +2 more
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Frontiers in Medicine, 2022 BackgroundLynch syndrome is an autosomal dominant disorder associated with a high incidence of various cancer types. Multiple variants of mismatch repair genes have been reported for Lynch syndrome. However, the diagnosis in patients with atypical cancer
Lu Li +7 more
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European Medical Journal, 2019 Primary cardiac tumours are exceedingly unusual and aggressive; they often develop in younger patients and present with advanced disease. The rarity and heterogeneity of primary cardiac tumours challenge the standardisation of therapeutic guidelines. Undifferentiated primary cardiac spindle cell sarcomas, a distinct subset of primary cardiac sarcomas ...
Emily Bryer, Lee Hartner
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Investigating the Link between Lynch Syndrome and Breast Cancer
European Journal of Breast Health, 2020 Objective:Lynch syndrome is an inherited genetic disorder associated with a predisposition to early-onset colorectal and endometrial cancers, but breast cancer risk in these patients is debated. The aim of this study is to evaluate breast cancer rates in
Megan Sheehan +7 more
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Molecular diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome)
Revista de la Facultad de Medicina, 2016 Lynch syndrome is the most common cause of inherited colorectal cancer, totaling 5 to 8% of all the cases with high susceptibility to this type of cancer and extracolonic cancer.
David Serrano, Clara Eugenia Arteaga
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Dermatology Research and Practice, 2010 Cutaneous neoplasms including sebaceous tumors, keratoacanthomas, and basal cell carcinomas with sebaceous differentiation can be markers of internal malignancy associated with the Muir-Torre Syndrome (MTS).
Michael C. Lynch, Bryan E. Anderson
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World Journal of Surgical Oncology, 2009 Background MLH1 is one of six known genes responsible for DNA mismatch repair (MMR), whose inactivation leads to HNPCC. It is important to develop genotype-phenotype correlations for HNPCC, as is being done for other hereditary cancer syndromes, in order
Yee Herman +6 more
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Systematic Review: An Update on the Spectrum of Urological Malignancies in Lynch Syndrome
Bladder Cancer, 2018 Background: Lynch syndrome is an autosomal dominant disorder that predisposes individuals affected to certain malignancies. Colon and endometrial cancers are the malignancies most highly associated with Lynch syndrome.
Dora Huang +3 more
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Generational Expression of Muir-Torre Syndrome in a Canadian Family
Case Reports in Dermatological Medicine, 2016 Muir-Torre syndrome (MTS) is a rare autosomal dominant inherited genodermatosis that is considered to be a phenotypic subtype of hereditary nonpolyposis colorectal cancer (HNPCC), commonly referred to as Lynch syndrome. We describe the clinical course of
Kaitlin Alexandra Vanderbeck +2 more
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Metastatic rectal cancer to papillary thyroid carcinoma: a case report and review of literature
BMC Gastroenterology, 2020 Background Tumor-to-tumor metastasis is a rare event. Rectal cancer to primary thyroid neoplasm metastasis is extremely rare. Herein, we reported a case of metastatic rectal adenocarcinoma to a papillary thyroid carcinoma.
Min Luo +3 more
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