Results 31 to 40 of about 7,899 (110)

Postradiation Histiocytic Sarcoma in the Setting of Muir-Torre Syndrome

Case Reports in Pathology, 2018
Hereditary nonpolyposis colorectal carcinoma (HNPCC) is an autosomal dominant genetic disorder characterized by a predisposition towards colorectal carcinoma and other extracolonic neoplasms.
Erin Baumgartner, David Ullman, Jeffrey Adam Jones, Danielle Fasciano, Daniel S. Atherton, Peter Pavlidakey, Deniz Peker   +6 more
doaj   +1 more source

Frequency of hematologic and solid malignancies in the family history of 50 patients with acute myeloid leukemia - a single center analysis.

PLoS ONE, 2019
Background and objectiveThe revised World Health Organization classification of 2016 for myeloid neoplasms and acute leukemia added a section of myeloid neoplasms with germline predisposition. The main objective of our study was to evaluate the frequency
Anne-Sophie Sandner, Ramona Weggel, Yasmin Mehraein, Stephanie Schneider, Wolfgang Hiddemann, Karsten Spiekermann   +5 more
doaj   +1 more source

Incidence and epidemiological features of synchronous and metachronous colorectal cancer

Journal of Coloproctology, 2013
Introduction: patients with sporadic colorectal cancer or cases associated with syndromes are at risk of having synchronous or metachronous cancer. Although it is an important subject, Brazilian data on the subject are scarce.
Eduardo Brambilla, Augusto Cardoso Sgarioni, Guilherme Finger, Guilherme Sartori, Maicon Joel Cimarosti   +4 more
doaj   +1 more source

Detección de mutaciones de los genes hMLH1 y hMSH2 del sistema de reparación de malos apareamientos del ADN en familias colombianas sospechosas de cancer colorrectal no polipósico hereditario (síndrome de Lynch).

Biomédica: revista del Instituto Nacional de Salud, 2005
Introducción. El cáncer colorrectal es la segunda causa de morbilidad y mortalidad por cáncer en los países desarrollados. En Colombia es la quinta causa de muerte entre los diferentes cánceres.
Andrea Gómez, Gustavo Salguero, Herbert García, Fabio Aristizábal, Oscar Gutiérrez, Luis Alberto Angel, Jorge Padrón, Carlos Martínez, Humberto Martínez, Omar Malaver, Rosa Barvo, Alejandro Giraldo   +11 more
doaj   +1 more source

Phenotypic Heterogeneity by Germline Mismatch Repair Gene Defect in Lynch Syndrome Patients

Acta Médica Portuguesa, 2016
Introduction: Lynch syndrome is the most common form of hereditary colorectal cancer, being also responsible for endometrial and other types of cancers. It is associated with germline mutations in DNA mismatch repair genes and microsatellite instability.
Jorge Hernâni-Eusébio, Elisabete Barbosa   +1 more
doaj   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Hereditary non-polipomatous colorectal cancer: hereditary predisposition, diagnosis and prevention Câncer colorretal hereditário não-polipomatoso: predisposição hereditária, diagnóstico e prevenção

Arquivos de Gastroenterologia, 2005
BACKGROUND: Colorectal cancer is the third in frequency and the second in mortality in developed countries. In Brazil, it is among the six more common malignant neoplasias. About 20% of colorectal tumors have some hereditary component.
Renata dos Santos Coura, Patricia Ashton-Prolla, João Carlos Prolla   +2 more
doaj   +1 more source

Familial Adenomatous Polyposis—Risk of Cancer, Cancer Prevention, and Long‐Term Consequences: Learnings from Five Decades with the Danish Polyposis Register

APMIS, Volume 134, Issue 5, May 2026.
ABSTRACT Familial adenomatous polyposis (FAP) is a hereditary condition marked by the growth of hundreds to thousands of adenomatous polyps in the colon and rectum, significantly elevating the risk of colorectal cancer (CRC) if left untreated. Caused by pathogenic variants in the APC gene, FAP is typically identified in adolescence, often leading to ...
John Gásdal Karstensen
wiley   +1 more source

Bacterial Infections Role in Gynecological Cancers Development: Narrative Review

Cancer Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background Gynecological cancers are among the most common cancers in women that affect female reproductive organs. The most common gynecological cancers are ovarian, cervical, uterine/endometrial, vaginal, and vulvar cancer. Women's reproductive organs have a dynamic and relative microbial balance.
Robab Azargun, Maryam Azargoon, Zahra Asefy, Mina Yekani, Vahideh Tarhriz, Fatemeh Yeganeh, Mohammad Yousef Memar, Shirin Eyvazi   +7 more
wiley   +1 more source

Toward Timely Diagnosis of Pancreatic Cancer: Revolutionizing Early Detection Through Genomics, Artificial Intelligence, and Noninvasive Biomarkers

Journal of Gastroenterology and Hepatology, Volume 41, Issue 3, Page 895-913, March 2026.
ABSTRACT Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive cancers, typically diagnosed at an advanced stage due to its subtle and often absent early symptoms. Despite representing only 3% of new cancer cases, it is projected to become the second leading cause of cancer‐related deaths by 2030.
Muhammad Masroor Hussain, Sana Qammar, Ju‐Mei Wang, Ao‐Qiang Zhai, Fu‐yu Li, Hai‐jie Hu   +5 more
wiley   +1 more source