Results 1 to 10 of about 72,850 (162)
DNA Mismatch Repair in Eukaryotes and Bacteria [PDF]
Journal of Nucleic Acids, 2010 DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved in almost all organisms ranging from bacteria to human ...
Kenji Fukui
doaj +3 more sources
DNA mismatch repair and the DNA damage response [PDF]
DNA Repair, 2016 This review discusses the role of DNA mismatch repair (MMR) in the DNA damage response (DDR) that triggers cell cycle arrest and, in some cases, apoptosis. Although the focus is on findings from mammalian cells, much has been learned from studies in other organisms including bacteria and yeast [1,2].
Peggy Hsieh
exaly +3 more sources
Action-At-A-Distance in DNA Mismatch Repair: Mechanistic Insights and Models for How DNA and Repair Proteins Facilitate Long-Range Communication [PDF]
BiomoleculesMany DNA metabolic pathways, including DNA repair, require the transmission of signals across long stretches of DNA or between DNA molecules. Solutions to this signaling challenge involve various mechanisms: protein factors can travel between these sites,
Bryce W. Collingwood +2 more
doaj +2 more sources
DNA mismatch repair in the context of chromatin [PDF]
Cell & Bioscience, 2020 DNA mismatch repair (MMR) maintains replication fidelity by correcting mispaired nucleotides incorporated by DNA polymerases. Defects in MMR lead to cancers characterized by microsatellite instability.
Yaping Huang, Guo-Min Li
doaj +3 more sources
MRE11A: a novel negative regulator of human DNA mismatch repair [PDF]
Cellular & Molecular Biology LettersBackground DNA mismatch repair (MMR) is a highly conserved pathway that corrects DNA replication errors, the loss of which is attributed to the development of various types of cancers. Although well characterized, MMR factors remain to be identified.
Demin Du +7 more
doaj +2 more sources
DNA Mismatch Repair Deficiency as a Biomarker in Sarcoma. [PDF]
Surg Oncol InsightLynch syndrome (LS) is a cancer predisposition syndrome caused by a germline loss-of-function mutation in a mismatch repair (MMR) gene. While sarcomas are not classically considered LS cancers, we investigated the MMR status and clinical features of sarcomas in LS patients to help inform optimal treatment strategies.A prospectively maintained ...
Denu RA +8 more
europepmc +4 more sources
ATP-Dependent Mismatch Recognition in DNA Replication Mismatch Repair
Quantum Reports, 2023 Mismatch repair is a critical step in DNA replication that occurs after base selection and proofreading, significantly increasing fidelity. However, the mechanism of mismatch recognition has not been established for any repair enzyme.
Nianqin Zhang, Yongjun Zhang
doaj +1 more source
Annals of Oncology Research and Therapy, 2021 Mismatch repair genes are responsible for discovering and repairing base mismatches during DNA replication in cells. Defects in mismatch repair function will lead to accumulation of gene mutations, microsatellite instability, and ultimately tumorigenesis.
Guangjie Liao, Jingqiu Yang, Xinke Zhang
doaj +1 more source
Annual Review of Biochemistry, 2005 ▪ Abstract  DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects mismatches generated during DNA replication and escape proofreading. MMR proteins also participate in many other DNA transactions, such that inactivation of MMR can have wide-ranging biological consequences, which can be either beneficial or detrimental.
Kunkel, Thomas A., Erie, Dorothy A.
openaire +2 more sources
DNA mismatch repair and infertility [PDF]
Current Opinion in Urology, 2010 To highlight the significance of the abnormal DNA repair mechanism in male infertility.DNA repair defects cause a variety of spermatogenic defects in mouse models. Evidence is accumulating to demonstrate the importance of DNA repair defects in human nonobstructive azoospermia.
Sarmistha, Mukherjee +2 more
openaire +2 more sources