C-terminal fluorescent labeling impairs functionality of DNA mismatch repair proteins [PDF]
, 2012 The human DNA mismatch repair (MMR) process is crucial to maintain the integrity of the genome and requires many different proteins which interact perfectly and coordinated.
Hinrichsen, Inga Malena +17 more
core +2 more sources
Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53 [PDF]
, 2013 YesThe antitumor prodrug temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (E.C.
Phillips, Roger M. +9 more
core +1 more source
Attaching and effacing Escherichia coli downregulate DNA mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans [PDF]
, 2009 Background: Mucosa-associated Escherichia coli are frequently found in the colonic mucosa of patients with colorectal adenocarcinoma, but rarely in healthy controls. Chronic mucosal E. coli infection has therefore been linked to colonic tumourigenesis. E.
Short, Abigail J. +14 more
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Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway
Cell Reports, 2017 Summary: DNA interstrand crosslinks (ICLs) that are repaired in non-dividing cells must be recognized independently of replication-associated DNA unwinding. Using cell-free extracts from Xenopus eggs that support neither replication nor transcription, we
Niyo Kato +11 more
doaj +1 more source
A function of thymine DNA glycosylase-initiated DNA repair in maintaining epigenome stability [PDF]
, 2013 The Thymine DNA Glycosylase (TDG) was initially discovered by its ability to excise the deamination products of cytosine and 5-methylcytosine (5-mC), and therefore thought to initiate base excision repair (BER) of the resulting G•U and G•T mismatches.
Jacobs, Angelika L.
core +1 more source
BMC Cancer, 2010 Background One of the most commonly used classes of anti-cancer drugs presently in clinical practice is the platinum-based drugs, including cisplatin.
Smith Jennifer M +2 more
doaj +1 more source
N‐terminus of hMLH1 confers interaction of hMutLα and hMutLβ with hMutSα [PDF]
, 2006 Mismatch repair is a highly conserved system that ensures replication fidelity by repairing mispairs after DNA synthesis. In humans, the two protein heterodimers hMutSα (hMSH2‐hMSH6) and hMutLα (hMLH1‐hPMS2) constitute the centre of the repair reaction ...
Trojan, Jörg +4 more
core +1 more source
Nature Communications, 2021 Defects in DNA mismatch repair (MMR) have been linked to inherited and sporadic cancers. Here the authors demonstrate that the DNA repair protein Rad27 (human FEN1) functions in one of three redundant mispair excision pathways, where its flap ...
Felipe A. Calil +6 more
doaj +1 more source
Apoptosis and DNA methylation [PDF]
, 2011 Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can ...
Meng, Huan X +18 more
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Escherichia coli frameshift mutation rate depends on the chromosomal context but not on the GATC content near the mutation site. [PDF]
PLoS ONE, 2012 Different studies have suggested that mutation rate varies at different positions in the genome. In this work we analyzed if the chromosomal context and/or the presence of GATC sites can affect the frameshift mutation rate in the Escherichia coli genome.
Mariana A Martina +3 more
doaj +1 more source