Results 1 to 10 of about 41,346 (265)

Coarse-grained molecular dynamics simulations of base-pair mismatch recognition protein MutS sliding along DNA [PDF]

Biophysics and Physicobiology, 2022
DNA mismatches are frequently generated by various intrinsic and extrinsic factors including DNA replication errors, oxygen species, ultraviolet, and ionizing radiation.
Keisuke Inoue, Shoji Takada, Tsuyoshi Terakawa   +2 more
doaj   +2 more sources

Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch [PDF]

Nature Communications, 2022
The structure of mismatched DNA-Polζ ternary complex provides a basis for understanding what makes Polζ adept at extending DNA synthesis past mismatched base pairs.
Radhika Malik, Robert E. Johnson, Louise Prakash, Satya Prakash, Iban Ubarretxena-Belandia, Aneel K. Aggarwal   +5 more
doaj   +2 more sources

Base-Pair Mismatch Can Destabilize Small DNA Loops through Cooperative Kinking [PDF]

Physical Review Letters, 2019
Harold Kim, Jiyoun Jeong
exaly   +2 more sources

Alleviation of C⋅C Mismatches in DNA by the Escherichia coli Fpg Protein

Frontiers in Microbiology, 2021
DNA polymerase III mis-insertion may, where not corrected by its 3′→ 5′ exonuclease or the mismatch repair (MMR) function, result in all possible non-cognate base pairs in DNA generating base substitutions.
Almaz Nigatu Tesfahun, Marina Alexeeva, Miglė Tomkuvienė, Aysha Arshad, Prashanna Guragain, Arne Klungland, Arne Klungland, Saulius Klimašauskas, Peter Ruoff, Svein Bjelland, Svein Bjelland   +10 more
doaj   +1 more source

The Research of G–Motif Construction and Chirality in Deoxyguanosine Monophosphate Nucleotide Complexes

Frontiers in Chemistry, 2021
A detailed understanding of the mismatched base-pairing interactions in DNA will help reveal genetic diseases and provide a theoretical basis for the development of targeted drugs.
Yanhong Zhu, Zhongkui Li, Pengfei Wang, Qi–Ming Qiu, Hongwei Ma, Hui Li   +5 more
doaj   +1 more source

Spontaneous and frequent conformational dynamics induced by A…A mismatch in d(CAA)·d(TAG) duplex

Scientific Reports, 2021
Base pair mismatches in DNA can erroneously be incorporated during replication, recombination, etc. Here, the influence of A…A mismatch in the context of 5′CAA·5′TAG sequence is explored using molecular dynamics (MD) simulation, umbrella sampling MD ...
Yogeeshwar Ajjugal, Kripi Tomar, D. Krishna Rao, Thenmalarchelvi Rathinavelan   +3 more
doaj   +1 more source

ATP-Dependent Mismatch Recognition in DNA Replication Mismatch Repair

Quantum Reports, 2023
Mismatch repair is a critical step in DNA replication that occurs after base selection and proofreading, significantly increasing fidelity. However, the mechanism of mismatch recognition has not been established for any repair enzyme.
Nianqin Zhang, Yongjun Zhang
doaj   +1 more source

A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase

Nature Communications, 2023
Artificially Expanded Genetic Information Systems (AEGIS) add independently replicable unnatural nucleotide pairs to the natural G:C and A:T/U pairs found in native DNA, joining the unnatural pairs through alternative modes of hydrogen bonding.
Juntaek Oh, Zelin Shan, Shuichi Hoshika, Jun Xu, Jenny Chong, Steven A. Benner, Dmitry Lyumkis, Dong Wang   +7 more
doaj   +1 more source

Unbranched rod-like RNA is required for RNA editing of hepatitis delta virus genotype 2 and genotype 4

Virus Research, 2023
RNA editing of the hepatitis delta virus (HDV) is essential for generating the large delta antigen, which is crucial for virion assembly. In HDV genotype 1 (HDV-1), editing occurs within the context of the unbranched rod-like structure characteristic of ...
Chao-Wei Hsu, Hsueh-Ying Hsu, Chien-Hung Chen, Mei Chao   +3 more
doaj   +1 more source

SNP Discrimination by Tolane-Modified Peptide Nucleic Acids: Application for the Detection of Drug Resistance in Pathogens

Molecules, 2020
During the treatment of viral or bacterial infections, it is important to evaluate any resistance to the therapeutic agents used. An amino acid substitution arising from a single base mutation in a particular gene often causes drug resistance in ...
Kenji Takagi, Tenko Hayashi, Shinjiro Sawada, Miku Okazaki, Sakiko Hori, Katsuya Ogata, Nobuo Kato, Yasuhito Ebara, Kunihiro Kaihatsu   +8 more
doaj   +1 more source