Results 11 to 20 of about 41,285 (266)
Virus Research, 2023 RNA editing of the hepatitis delta virus (HDV) is essential for generating the large delta antigen, which is crucial for virion assembly. In HDV genotype 1 (HDV-1), editing occurs within the context of the unbranched rod-like structure characteristic of ...
Chao-Wei Hsu +3 more
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Preferential base pairing modes of T·T mismatches [PDF]
FEBS Letters, 2011 It has long been recognized that T·T mismatches can adopt two different modes of exchangeable wobble base pairs in which no preferential pairing mode has been observed. In this study, we have performed a systematic nuclear magnetic resonance (NMR) investigation to study the sequence context effect on the pairing modes of T·T mismatches.
He, Guoyun, Kwok, Chun Kit, Lam, Sik Lok
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Molecules, 2020 During the treatment of viral or bacterial infections, it is important to evaluate any resistance to the therapeutic agents used. An amino acid substitution arising from a single base mutation in a particular gene often causes drug resistance in ...
Kenji Takagi +8 more
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pH-Responsive DNA Motif: From Rational Design to Analytical Applications
Frontiers in Chemistry, 2021 pH-responsive DNA motifs have attracted substantial attention attributed to their high designability and versatility of DNA chemistry. Such DNA motifs typically exploit DNA secondary structures that exhibit pH response properties because of the presence ...
Lin Lin Zheng +5 more
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Optimization of Single-Base-Pair Mismatch Discrimination in Oligonucleotide Microarrays [PDF]
Applied and Environmental Microbiology, 2003 ABSTRACT The discrimination between perfect-match and single-base-pair-mismatched nucleic acid duplexes was investigated by using oligonucleotide DNA microarrays and nonequilibrium dissociation rates (melting profiles).
Urakawa, H. +7 more
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Sequence-Dependent T:G Base Pair Opening in DNA Double Helix Bound by Cren7, a Chromatin Protein Conserved among Crenarchaea. [PDF]
PLoS ONE, 2016 T:G base pair arising from spontaneous deamination of 5mC or polymerase errors is a great challenge for DNA repair of hyperthermophilic archaea, especially Crenarchaea.
Lei Tian +5 more
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A rule of seven in Watson-Crick base-pairing of mismatched sequences [PDF]
Nature Structural & Molecular Biology, 2012 Sequence recognition through base-pairing is essential for DNA repair and gene regulation, but the basic rules governing this process remain elusive. In particular, the kinetics of annealing between two imperfectly matched strands is not well characterized, despite its potential importance in nucleic acid-based biotechnologies and gene silencing.
Cisse, Ibrahim I. +2 more
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Base-Pair Mismatch in DNA at 2.3A Resolution
Nucleosides and Nucleotides, 1985 Abstract X-ray single crystal analysis of the deoxyoctanucleotide d(GGGGCTCC)2 has revealed, for the first time, the existence of the G.T wobble mispair in an A-DNA double helical fragment.
Brown, T +3 more
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Molecules, 2020 To understand the complex fluorescence properties of astraphloxin (CY3)-labelled oligonucleotides, it is necessary to take into account the redox properties of the nucleobases.
Jens Sobek, Ralph Schlapbach
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Scientific Reports, 2023 Proton transfer across hydrogen bonds in DNA can produce non-canonical nucleobase dimers and is a possible source of single-point mutations when these forms mismatch under replication.
Max Winokan +3 more
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