Results 11 to 20 of about 41,346 (265)
Importance of base-pair opening for mismatch recognition [PDF]
Nucleic Acids Research, 2020 AbstractMismatch repair is a highly conserved cellular pathway responsible for repairing mismatched dsDNA. Errors are detected by the MutS enzyme, which most likely senses altered mechanical property of damaged dsDNA rather than a specific molecular pattern.
Tomáš Bouchal +4 more
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SPR fingerprinting of mismatched base pair [PDF]
Nucleic Acids Symposium Series, 2004 Discrimination of mismatched base pairs having various flanking sequence from normal Watson-Crick base pairs were examined using SPR sensor surface where mismatch binding ligand (MBL) were immobilized. CC, CT, and TT mismatched base pair are distinguishable from wild type DNA by means of diaminonaphthyndine dimer (damND) immobilized sensor surface.
Akio, Kobori +3 more
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Preferential base pairing modes of T·T mismatches [PDF]
FEBS Letters, 2011 It has long been recognized that T·T mismatches can adopt two different modes of exchangeable wobble base pairs in which no preferential pairing mode has been observed. In this study, we have performed a systematic nuclear magnetic resonance (NMR) investigation to study the sequence context effect on the pairing modes of T·T mismatches.
He, Guoyun, Kwok, Chun Kit, Lam, Sik Lok
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pH-Responsive DNA Motif: From Rational Design to Analytical Applications
Frontiers in Chemistry, 2021 pH-responsive DNA motifs have attracted substantial attention attributed to their high designability and versatility of DNA chemistry. Such DNA motifs typically exploit DNA secondary structures that exhibit pH response properties because of the presence ...
Lin Lin Zheng +5 more
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Sequence-Dependent T:G Base Pair Opening in DNA Double Helix Bound by Cren7, a Chromatin Protein Conserved among Crenarchaea. [PDF]
PLoS ONE, 2016 T:G base pair arising from spontaneous deamination of 5mC or polymerase errors is a great challenge for DNA repair of hyperthermophilic archaea, especially Crenarchaea.
Lei Tian +5 more
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Optimization of Single-Base-Pair Mismatch Discrimination in Oligonucleotide Microarrays [PDF]
Applied and Environmental Microbiology, 2003 ABSTRACT The discrimination between perfect-match and single-base-pair-mismatched nucleic acid duplexes was investigated by using oligonucleotide DNA microarrays and nonequilibrium dissociation rates (melting profiles).
Urakawa, H. +7 more
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A rule of seven in Watson-Crick base-pairing of mismatched sequences [PDF]
Nature Structural & Molecular Biology, 2012 Sequence recognition through base-pairing is essential for DNA repair and gene regulation, but the basic rules governing this process remain elusive. In particular, the kinetics of annealing between two imperfectly matched strands is not well characterized, despite its potential importance in nucleic acid-based biotechnologies and gene silencing.
Cisse, Ibrahim I. +2 more
openaire +3 more sources
Base-Pair Mismatch in DNA at 2.3A Resolution
Nucleosides and Nucleotides, 1985 Abstract X-ray single crystal analysis of the deoxyoctanucleotide d(GGGGCTCC)2 has revealed, for the first time, the existence of the G.T wobble mispair in an A-DNA double helical fragment.
Brown, T +3 more
openaire +1 more source
Molecules, 2020 To understand the complex fluorescence properties of astraphloxin (CY3)-labelled oligonucleotides, it is necessary to take into account the redox properties of the nucleobases.
Jens Sobek, Ralph Schlapbach
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Scientific Reports, 2023 Proton transfer across hydrogen bonds in DNA can produce non-canonical nucleobase dimers and is a possible source of single-point mutations when these forms mismatch under replication.
Max Winokan +3 more
doaj +1 more source