PLoS ONE, 2017 The effect of S-substitution on the O6 guanine site of a 13-mer DNA duplex containing a G:T mismatch is studied using molecular dynamics. The structure, dynamic evolution and hydration of the S-substituted duplex are compared with those of a normal ...
Elaine Ann Moore, Yao-Zhong Xu
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Base-Pair Mismatch in DNA at 2.3A Resolution
Nucleosides and Nucleotides, 1985 Abstract X-ray single crystal analysis of the deoxyoctanucleotide d(GGGGCTCC)2 has revealed, for the first time, the existence of the G.T wobble mispair in an A-DNA double helical fragment.
Brown, T +3 more
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Semiconservative Replication in the Quasispecies Model [PDF]
, 2003 This paper extends Eigen's quasispecies equations to account for the semiconservative nature of DNA replication. We solve the equations in the limit of infinite sequence length for the simplest case of a static, sharply peaked fitness landscape.
Deeds, Eric J. +2 more
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Imidazole-imidazole pair as a minor groove recognition motif for T:G mismatched base pairs [PDF]
Nucleic Acids Research, 1999 The T:G mismatched base pair is associated with many genetic mutations. Understanding its biological consequences may be aided by studying the structural perturbation of DNA caused by a T:G base pair and by specific probing of the mismatch using small molecular ligands.
X L, Yang +5 more
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Statistical evaluation and biological interpretation of non-random abundance in the E. coli K-12 genome of tetra- and pentanucleotide sequences related to VSP DNA mismatch repair [PDF]
, 1992 The abundance of all tetra- and pentanucleotide sequences is calculated for a set of DNA sequence data comprising 767,393 nucleotides of the E. coli K-12 genome. Observed frequencies are compared to those expected from a Markov chain prediction algorithm.
Merkl, Rainer +3 more
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Recognition of Mismatched Base Pairs in DNA [PDF]
Bulletin of the Chemical Society of Japan, 2009 Abstract Mismatch binding ligand (MBL) selectively binds to mismatched base pairs with discrimination of the nucleotide bases composing the mismatch. This review focuses on the inside story regarding the molecular design of MBL and its function, and potential application in genomic science.
openaire +1 more source
The impact of mutation and gene conversion on the local diversification of antigen genes in African trypanosomes [PDF]
, 2012 Patterns of genetic diversity in parasite antigen gene families hold important information about their potential to generate antigenic variation within and between hosts.
Awadalla +12 more
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Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice
Genes and Environment, 2021 Background Base pair mismatches in genomic DNA can result in mutagenesis, and consequently in tumorigenesis. To investigate how mismatch repair deficiency increases mutagenicity under oxidative stress, we examined the type and frequency of mutations ...
Yasunobu Aoki +6 more
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Metallo-intercalators and metallo-insertors [PDF]
, 2007 Since the elucidation of the structure of double helical DNA, the construction of small molecules that recognize and react at specific DNA sites has been an area of considerable interest.
Barton, Jacqueline K. +2 more
core +1 more source
Insights into DNA platination within unusual structural settings [PDF]
, 2011 2D [1H, 15N] HSQC NMR spectroscopy has been used to monitor reaction and product formation between [Pt(15NH3)2I2] and nucleic acids possessing irregular topologies and containing site specific phosphorothioate substitution in the phosphodiester backbone.
Harvie, Stephanie +2 more
core +2 more sources