Results 21 to 30 of about 168,088 (301)
Dissociation kinetics of 19 base paired oligonucleotide-DNA duplexes containing different single mismatched base pairs [PDF]
Nucleic Acids Research, 1987 The dissociation kinetics of 19 base paired oligonucleotide-DNA duplex containing a various single mismatched base pair are studied on dried agarose gels. The kinetics of the dissociation are first order under our experimental conditions. The incorporation of a single mismatched base pair destabilizes the DNA duplexes to some extent, the amount ...
S, Ikuta +3 more
openaire +2 more sources
Equilibrium Distribution of Mutators in the Single Fitness Peak Model [PDF]
, 2003 This paper develops an analytically tractable model for determining the equilibrium distribution of mismatch repair deficient strains in unicellular populations. The approach is based on the single fitness peak (SFP) model, which has been used in Eigen's
D. Voet +3 more
core +2 more sources
Mismatched DNA Base Pairs Show Increased Conformational Fluctuations [PDF]
Biophysical Journal, 2015 Base pair mismatches in DNA can have many adverse consequences, yet the exact mechanism by which mismatches are repaired is unknown. Both matched and mismatched DNA sequences were studied using molecular dynamics in biased and unbiased simulation. Significant differences were found between matched and mismatched pairs in structure, hydrogen bonding ...
Kingsland, Adelaide, Maibaum, Lutz
openaire +1 more source
Sequence specific fluorescence detection of double strand DNA [PDF]
, 2003 Methods for the fluorescent detection of specific sequences of double strand DNA in homogeneous solution may be useful in the field of human genetics. A series of hairpin polyamides with tetramethyl rhodamine (TMR) attached to an internal pyrrole ring ...
Dervan, Peter B. +3 more
core +1 more source
Unanticipated differences between α- and γ-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates [PDF]
, 2006 Hairpin polyamide–chlorambucil conjugates containing an {alpha}-diaminobutyric acid ({alpha}-DABA) turn moiety are compared to their constitutional isomers containing the well-characterized {gamma}-DABA turn.
Chou, C. James +4 more
core +4 more sources
Molecules, 2020 To understand the complex fluorescence properties of astraphloxin (CY3)-labelled oligonucleotides, it is necessary to take into account the redox properties of the nucleobases.
Jens Sobek, Ralph Schlapbach
doaj +1 more source
Scientific Reports, 2023 Proton transfer across hydrogen bonds in DNA can produce non-canonical nucleobase dimers and is a possible source of single-point mutations when these forms mismatch under replication.
Max Winokan +3 more
doaj +1 more source
Guanine- 5-carboxylcytosine base pairs mimic mismatches during DNA replication [PDF]
Scientific Reports, 2014 AbstractThe genetic information encoded in genomes must be faithfully replicated and transmitted to daughter cells. The recent discovery of consecutive DNA conversions by TET family proteins of 5-methylcytosine into 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine (5caC) suggests these modified cytosines act as DNA lesions, which could ...
Shibutani, Toshihiro +13 more
openaire +2 more sources
DNA-Mediated Electrochemistry [PDF]
, 2008 The base pair stack of DNA has been demonstrated as a medium for long-range charge transport chemistry both in solution and at DNA-modified surfaces. This chemistry is exquisitely sensitive to structural perturbations in the base pair stack as occur with
Barton, Jacqueline K. +2 more
core +2 more sources
Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. [PDF]
, 2020 Appropriate empirical-based evidence and detailed theoretical considerations should be used for evolutionary explanations of phenotypic variation observed in the field of human population genetics (especially Indigenous populations). Investigators within
Fox, Keolu +2 more
core +2 more sources