Results 41 to 50 of about 168,088 (301)
Biomédica: revista del Instituto Nacional de Salud, 2005 Introducción. El cáncer colorrectal es la segunda causa de morbilidad y mortalidad por cáncer en los países desarrollados. En Colombia es la quinta causa de muerte entre los diferentes cánceres.
Andrea Gómez +11 more
doaj +1 more source
Selective Preference of Parallel DNA Triplexes Is Due to the Disruption of Hoogsteen Hydrogen Bonds Caused by the Severe Nonisostericity between the G*GC and T*AT Triplets. [PDF]
PLoS ONE, 2016 Implications of DNA, RNA and RNA.DNA hybrid triplexes in diverse biological functions, diseases and therapeutic applications call for a thorough understanding of their structure-function relationships. Despite exhaustive studies mechanistic rationale for
Gunaseelan Goldsmith +2 more
doaj +1 more source
High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast. [PDF]
, 2017 In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule.
Dominska, Margaret +3 more
core +3 more sources
Defects Can Increase the Melting Temperature of DNA-Nanoparticle Assemblies
, 2007 DNA-gold nanoparticle assemblies have shown promise as an alternative technology to DNA microarrays for DNA detection and RNA profiling. Understanding the effect of DNA sequences on the melting temperature of the system is central to developing reliable ...
Harris, Nolan C., Kiang, Ching-Hwa
core +1 more source
Multiplexed DNA-Modified Electrodes [PDF]
, 2010 We report the use of silicon chips with 16 DNA-modified electrodes (DME chips) utilizing DNA-mediated charge transport for multiplexed detection of DNA and DNA-binding protein targets.
Barton, Jacqueline K. +3 more
core +2 more sources
Detection of the C-C mismatched base pair by small ligands [PDF]
Nucleic Acids Symposium Series, 2003 We synthesized 2-aminonaphthyridine derivatives that specifically bind to cytosine-cytosine (C-C) mismatch. The binding of ligands was verified by observing an increase of melting temperature for 11-mer duplexes containing a mismatch in the presence of ligands.
Akio, Kobori +3 more
openaire +2 more sources
Recognition of abasic sites and single base bulges in DNA by a metalloinsertor [PDF]
, 2009 Abasic sites and single base bulges are thermodynamically destabilizing DNA defects that can lead to cancerous transformations if left unrepaired by the cell.
Barton, Jacqueline K. +2 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
PLoS Computational Biology, 2021 Specific interaction between the start codon, 5'-AUG-3', and the anticodon, 5'-CAU-3', ensures accurate initiation of translation. Recent studies show that several near-cognate start codons (e.g.
Takeru Kameda +2 more
doaj +1 more source
Photoinduced excess electron injection into DNA duplexes containing mismatched base pairs [PDF]
Nucleic Acids Symposium Series, 2008 A series of DNA containing photoinduced electron donors and mismatched DNA base pairs have been prepared and applied for the chemical investigation of excess electron transfer (EET) in the duplex DNA. As the electron donors, phenothiazine (PTZ) with a flexible linker was tethered to the 5'-end or in the middle of the sequences, or diaminostilbene (DAS)
Takeo, Ito +5 more
openaire +2 more sources