Results 11 to 20 of about 72,949 (261)
Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair
Nature Communications, 2022 Prime Editing is a versatile genome engineering tool. Here, the authors identify the DNA repair pathway known as mismatch repair as inhibitory for Prime Editing, thus, loss of mismatch repair enhances the efficiency of Prime Editing.
J. Ferreira da Silva +7 more
doaj +1 more source
The Startling Role of Mismatch Repair in Trinucleotide Repeat Expansions
Cells, 2021 Trinucleotide repeats are a peculiar class of microsatellites whose expansions are responsible for approximately 30 human neurological or developmental disorders.
Guy-Franck Richard
doaj +1 more source
Alleviation of C⋅C Mismatches in DNA by the Escherichia coli Fpg Protein
Frontiers in Microbiology, 2021 DNA polymerase III mis-insertion may, where not corrected by its 3′→ 5′ exonuclease or the mismatch repair (MMR) function, result in all possible non-cognate base pairs in DNA generating base substitutions.
Almaz Nigatu Tesfahun +10 more
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Strand asymmetry influences mismatch resolution during a single-strand annealing
Genome Biology, 2022 Background Biases of DNA repair can shape the nucleotide landscape of genomes at evolutionary timescales. The molecular mechanisms of those biases are still poorly understood because it is difficult to isolate the contributions of DNA repair from those ...
Victoria O. Pokusaeva +4 more
doaj +1 more source
Frontiers in Immunology, 2022 Cancer cells harbor genomic instability due to accumulated DNA damage, one of the cancer hallmarks. At least five major DNA Damage Repair (DDR) pathways are recognized to repair DNA damages during different stages of the cell cycle, comprehending base ...
Saulo Brito Silva +2 more
doaj +1 more source
An Msh3 ATPase domain mutation has no effect on MMR function
BMC Research Notes, 2017 Objective To demonstrate that the Msh3 ATPase domain is required for DNA mismatch repair and tumor suppression in a murine model. Results The DNA mismatch repair proteins are members of the ABC family of ATPases.
Yasmin Edwards
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Data in Brief, 2020 We recently found that DNA repair-related gene expression could be altered by reprogramming as well as the increased expression of genes that accurately convey genomic information, such as homologous recombination (HR) and mismatch repair (MMR), and the ...
Yasuhide Yoshimura, Daisuke Okuzaki
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Downregulation of both mismatch repair and non-homologous end-joining pathways in hypoxic brain tumour cell lines [PDF]
PeerJ, 2021 Glioblastoma, a grade IV astrocytoma, has a poor survival rate in part due to ineffective treatment options available. These tumours are heterogeneous with areas of low oxygen levels, termed hypoxic regions.
Sophie Cowman +2 more
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EcoSal Plus, 2012 DNA mismatch repair (MMR) corrects replication errors in newly synthesized DNA. It also has an antirecombination action on heteroduplexes that contain similar but not identical sequences. This review focuses on the genetics and development of MMR and not on the latest biochemical mechanisms.
openaire +2 more sources
Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway
Cell Reports, 2017 Summary: DNA interstrand crosslinks (ICLs) that are repaired in non-dividing cells must be recognized independently of replication-associated DNA unwinding. Using cell-free extracts from Xenopus eggs that support neither replication nor transcription, we
Niyo Kato +11 more
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