Results 11 to 20 of about 141,580 (256)

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

What is currently known about endometrial cancer in Lynch syndrome? - review

Journal of Education, Health and Sport, 2019
Introduction: About 5% of endometrial cancer cases can be genetic and inherited. Lynch syndrome, also called hereditary non-polyposis colorectal cancer (HNPCC), is an autosomal dominant syndrome.
Agnieszka Kwiatkowska, Dominika Krawczyk, Krzysztof Kułak, Sylwester Makuch, Klaudia Sapko   +4 more
doaj   +3 more sources

Telomere length and genetic anticipation in lynch syndrome [PDF]

, 2016
Telomere length variation has been associated with increased risk of several types of tumors, and telomere shortening, with genetic anticipation in a number of genetic diseases including hereditary cancer syndromes.
Bellido Molías, Fernando, Blanco Guillermo, Ignacio, Borràs Flores, Ester, Capellá, G. (Gabriel), Guinó, Elisabet, Lázaro García, Conxi, Moreno Aguado, Víctor, Navarro, Matilde, Pineda Riu, Marta, Seguí Gracia, Nuria, Valle Velasco, Laura   +10 more
core   +1 more source

Immunology of Lynch Syndrome [PDF]

Current Oncology Reports, 2021
Abstract Purpose of Review Patients with Lynch syndrome have a high probability of developing colorectal and other carcinomas. This review provides a comprehensive assessment of the immunologic aspects of Lynch syndrome pathogenesis and provides an overview of potential immune interventions for patients with Lynch ...
Danielle M. Pastor, Jeffrey Schlom
openaire   +2 more sources

Comprehensive population-wide analysis of Lynch syndrome in Iceland reveals founder mutations in MSH6 and PMS2. [PDF]

, 2017
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked FilesLynch syndrome, caused by germline mutations in the mismatch repair genes, is ...
Alexiusdottir, Kristin, Arngrimsson, Reynir, Bekaii-Saab, Tanios, de la Chapelle, Albert, Einarsdottir, Sylvia, Frankel, Wendy L, Goldberg, Richard M, Hampel, Heather, Haraldsdottir, Sigurdis, Haraldsson, Stefan, Hitchins, Megan, Jonasson, Jon G, Kehr, Birte, Masson, Gisli, Moller, Pall H, Pritchard, Colin C, Rafnar, Thorunn, Shields, Peter G, Sigurdsson, Asgeir, Sigurdsson, Fridbjorn, Snaebjornsson, Petur, Stefansson, Kari, Stefansson, Tryggvi, Steinarsdottir, Margret, Sulem, Patrick, Weng, Daniel, Yilmaz, Ahmet   +26 more
core   +2 more sources

Case report: Undifferentiated sarcoma with multiple tumors involved in Lynch syndrome: Unexpected favorable outcome to sintilimab combined with chemotherapy

Frontiers in Oncology, 2022
BackgroundPatients with Lynch syndrome are at an increased risk of developing simultaneous or metachronous tumors, while sarcomas have been occasionally reported.
Jiaying Liu, Xiaona Chang, Guixiang Xiao, Jingmin Zhong, Bo Huang, Jiwei Zhang, Beibei Gao, Gang Peng, Xiu Nie   +8 more
doaj   +1 more source

Outcomes from the English National Lynch Syndrome transformation project. [PDF]

Int J Cancer
What's new? The elevated cancer risk conferred by Lynch syndrome can be mitigated through preventive interventions. However, Lynch syndrome often goes underdiagnosed. The National Lynch Syndrome Transformation Project in England aims to ensure that patients newly diagnosed with colorectal or endometrial cancer are offered testing for the syndrome ...
Monahan KJ, Fleming P, Ryan NAJ, Monje-Garcia L, Armstrong R, Church DN, Cook J, Lalloo F, Lane S, McDermott FD, Miles T, Mallinson C, Hardy SA, Gelinas S, Faravelli F, Elmslie F, Shaw AC.   +16 more
europepmc   +2 more sources

Molecular Alterations and Association with Clinical Parameters [PDF]

, 2015
Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes, most frequently MLH1 and MSH2. Recently, MMR-deficient crypt foci (MMR- DCF) have been identified as a novel lesion which occurs at high frequency in the intestinal mucosa
Benner, Axel, Bläker, Hendrik, Echterdiek, Fabian, Grabe, Niels, Kloor, Matthias, Knebel Doeberitz, Magnus von, Lahrmann, Bernd, Nelius, Nina, Schneider, Martin, Staffa, Laura, Tariverdian, Mirjam, Werft, Wiebke   +11 more
core   +1 more source

Same Gene Mutation But Variable Phenotypes in 2 Families With Lynch Syndrome: Two Case Reports and Review of Genotype-Phenotype Correlation

Clinical Medicine Insights: Case Reports, 2018
Lynch syndrome is an autosomal dominant syndrome that can be subdivided into Lynch syndrome I, or site-specific colonic cancer, and Lynch syndrome II, or extracolonic cancers, particularly carcinomas of the stomach, endometrium, biliary and pancreatic ...
Raffaella Liccardo, Marina De Rosa, Francesca Duraturo   +2 more
doaj   +1 more source

IDH1 mutated low grade astrocytoma occurring in MSH2 mutated Lynch syndrome family

Human Pathology: Case Reports, 2016
Lynch syndrome (LS) is an autosomal dominant tumour predisposition syndrome caused by a germline mutation in one of the DNA mismatch repair (MMR) genes.Patients with these mutations have an increased risk of brain tumours, the vast majority of which are ...
Alaa Alkhotani, Ingrid Ambus, Lea Velsher, Corwyn Rowsell, Julia Keith   +4 more
doaj   +1 more source