Results 11 to 20 of about 37,501 (261)
Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients [PDF]
Clinical and Developmental Immunology, 2010 High levels of microsatellite instability (MSI-high) are a cardinal feature of colorectal tumors from patients with Lynch Syndrome. Other key characteristics of Lynch Syndrome are that these patients experience fewer metastases and have enhanced survival
Kristen M. Drescher +2 more
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Molecular diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome) [PDF]
Revista de la Facultad de Medicina, 2016 Lynch syndrome is the most common cause of inherited colorectal cancer, totaling 5 to 8% of all the cases with high susceptibility to this type of cancer and extracolonic cancer.
David Serrano, Clara Eugenia Arteaga
doaj +2 more sources
Circulating metabolome landscape in Lynch syndrome
Cancer & MetabolismCirculating metabolites systemically reflect cellular processes and can modulate the tissue microenvironment in complex ways, potentially impacting cancer initiation processes.
Tiina A. Jokela +6 more
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Unusual presentation of Lynch Syndrome [PDF]
Hereditary Cancer in Clinical Practice, 2009 Lynch Syndrome/HNPCC is a syndrome of cancer predisposition linked to inherited mutations of genes participating in post-replicative DNA mismatch repair (MMR).
Yu Veronica PCC +10 more
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Recent advances in Lynch syndrome
Experimental Hematology & Oncology, 2021 Lynch syndrome is one of the most common hereditary cancer syndromes and is characterized by the development of many cancers, such as colorectal cancer (CRC), endometrial cancer, ovarian cancer, stomach cancer and many other cancers.
Xi Li, Guodong Liu, Wei Wu
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Molecular subtype classification of urothelial carcinoma in Lynch syndrome [PDF]
Molecular Oncology, 2018 Lynch syndrome confers an increased risk for urothelial carcinoma (UC). Molecular subtypes may be relevant to prognosis and therapeutic possibilities, but have to date not been defined in Lynch syndrome‐associated urothelial cancer. We aimed to provide a
Christina Therkildsen +6 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018 Lynch syndrome (LS) is an autosomal-dominant disease characterized by an increased cancer susceptibility, particularly of the colon and endometrium. LS is caused by a constitutional heterozygous loss-of-function mutation or epimutation in one of the DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6 or PMS2).
Nutter, Raejeanne B.
openaire +4 more sources
The genetic basis of Lynch syndrome and its implications for clinical practice and risk management
The Application of Clinical Genetics, 2014 Stephanie A Cohen,1 Anna Leininger2 1Cancer Genetics Risk Assessment Program, St Vincent Health, Indianapolis, IN, USA; 2Minnesota Oncology, Woodbury, MN, USA Abstract: Lynch syndrome is the most common cause of hereditary colon cancer, and accounts for
Cohen SA, Leininger A
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Genetic Counseling and Surveillance Focused on Lynch Syndrome
Journal of the Anus, Rectum and Colon, 2019 Lynch syndrome is a hereditary cancer syndrome caused by germline mutations in one of several DNA mismatch repair genes. Lynch syndrome leads to an increased lifetime risk of various cancers, particularly colorectal, and endometrial cancers.
Jin Yong Kim, Jeong-Sik Byeon
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BJS (British Journal of Surgery), EarlyView., 2020 Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä +18 more
wiley +1 more source