Results 11 to 20 of about 31,569 (215)

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

What is currently known about endometrial cancer in Lynch syndrome? - review

Journal of Education, Health and Sport, 2019
Introduction: About 5% of endometrial cancer cases can be genetic and inherited. Lynch syndrome, also called hereditary non-polyposis colorectal cancer (HNPCC), is an autosomal dominant syndrome.
Agnieszka Kwiatkowska, Dominika Krawczyk, Krzysztof Kułak, Sylwester Makuch, Klaudia Sapko   +4 more
doaj   +3 more sources

Same Gene Mutation But Variable Phenotypes in 2 Families With Lynch Syndrome: Two Case Reports and Review of Genotype-Phenotype Correlation

Clinical Medicine Insights: Case Reports, 2018
Lynch syndrome is an autosomal dominant syndrome that can be subdivided into Lynch syndrome I, or site-specific colonic cancer, and Lynch syndrome II, or extracolonic cancers, particularly carcinomas of the stomach, endometrium, biliary and pancreatic ...
Raffaella Liccardo, Marina De Rosa, Francesca Duraturo   +2 more
doaj   +1 more source

Case report: Undifferentiated sarcoma with multiple tumors involved in Lynch syndrome: Unexpected favorable outcome to sintilimab combined with chemotherapy

Frontiers in Oncology, 2022
BackgroundPatients with Lynch syndrome are at an increased risk of developing simultaneous or metachronous tumors, while sarcomas have been occasionally reported.
Jiaying Liu, Xiaona Chang, Guixiang Xiao, Jingmin Zhong, Bo Huang, Jiwei Zhang, Beibei Gao, Gang Peng, Xiu Nie   +8 more
doaj   +1 more source

Molecular subtype classification of urothelial carcinoma in Lynch syndrome

Molecular Oncology, 2018
Lynch syndrome confers an increased risk for urothelial carcinoma (UC). Molecular subtypes may be relevant to prognosis and therapeutic possibilities, but have to date not been defined in Lynch syndrome‐associated urothelial cancer. We aimed to provide a
Christina Therkildsen, Pontus Eriksson, Mattias Höglund, Mats Jönsson, Gottfrid Sjödahl, Mef Nilbert, Fredrik Liedberg   +6 more
doaj   +1 more source

IDH1 mutated low grade astrocytoma occurring in MSH2 mutated Lynch syndrome family

Human Pathology: Case Reports, 2016
Lynch syndrome (LS) is an autosomal dominant tumour predisposition syndrome caused by a germline mutation in one of the DNA mismatch repair (MMR) genes.Patients with these mutations have an increased risk of brain tumours, the vast majority of which are ...
Alaa Alkhotani, Ingrid Ambus, Lea Velsher, Corwyn Rowsell, Julia Keith   +4 more
doaj   +1 more source

An update on Lynch syndrome

Current Opinion in Oncology, 1998
Recent advances in hereditary nonpolyposis colorectal cancer (HNPCC) have been made based on the discovery early in this decade that germline mutations in genes responsible for repair of DNA mismatches formed the molecular basis for the syndrome. Several studies during the past year described the prevalence of germline mutations in those deemed at risk
H T, Lynch, T, Smyrk
openaire   +3 more sources

Lynch syndrome: An unusal case of familial cancer unearthed

Indian Journal of Pathology and Microbiology, 2022
Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) is a type of inherited cancer syndrome with a genetic predisposition to different types of cancer.
Subhra Dhar, Ashraf U Mannan, J Jaya Singh, Sandipan Dhar, Swetalina Pradhan   +4 more
doaj   +1 more source

An Update on Immune Checkpoint Therapy for the Treatment of Lynch Syndrome

Clinical and Experimental Gastroenterology, 2021
Christina Therkildsen,1,2 Lars Henrik Jensen,3 Maria Rasmussen,2 Inge Bernstein4,5 1Department of Surgical Gastroenterology, Copenhagen University Hospital, Copenhagen, Denmark; 2The Danish HNPCC Register, Department of Clinical Research, Copenhagen ...
Therkildsen C, Jensen LH, Rasmussen M, Bernstein I   +3 more
doaj  

Patient-physician relationships, health self-efficacy, and gynecologic cancer screening among women with Lynch syndrome

Hereditary Cancer in Clinical Practice, 2019
Background Lynch syndrome, a hereditary cancer syndrome, predisposes women to colorectal, endometrial, and ovarian cancer. Current guidelines recommend that women with Lynch syndrome undergo risk-reducing gynecological surgery to reduce their chances of ...
Kaitlin M. McGarragle, Melyssa Aronson, Kara Semotiuk, Spring Holter, Crystal J. Hare, Sarah E. Ferguson, Zane Cohen, Tae L. Hart   +7 more
doaj   +1 more source