Results 21 to 30 of about 37,501 (261)

Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome [PDF]

, 2020
BACKGROUND & AIMS: Lynch syndrome is caused by variants in DNA mismatch repair (MMR) genes and associated with an increased risk of colorectal cancer (CRC). In patients with Lynch syndrome, CRCs can develop via different pathways. We studied associations
Dutch Lynch Syndrome Collaborative, Ahadova, Aysel, Finnish Lynch Syndrome Registry, Lepistö, Anna, Renkonen-Sinisalo, Laura, Engel, Christoph, Seppälä, Toni T., Vasen, Hans F., German HNPCC Consortium   +8 more
core   +1 more source

Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts [PDF]

, 2013
Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2.
Sampson, JR, Capella, G., Moeslein, Gabriela, Moslein, G., Vasen, Hans F. A., Sijmons RH, Renkonen-Sinisalo, L, Genuardi, M, Engel, C., Leon, M., Møller P, Gopie, JP, Bertario, Lucio, Alonso A, Heinimann, K, Genuardi, M., Tejpar, S, Burn J, Rahner, N, Engel, Christoph, PONZ DE LEON, Maurizio, Alonso, A, Wijnen, J.T., Burn, John, Lindblom, Annika, Heinimann, Karl, Lindblom, A, Tejpar, Sabine, Vasen HF, Bertario L, Leon, M.P. de, Thomas HJ, Maurizio Genuardi., Nagengast, FM, Gopie JP, Myrhoj, T., Bernstein I, Hes, Frederik J., Stormorken, Astrid, Myrhoj, Torben, Aktan-Collan, Katja, Wijnen JT, Alonso, A., Tejpar, S., Hodgson, SV, Nagengast, Fokko M., Aretz, S., Vasen, H.F., Myrhoj T, Stormorken A, Moller, P., Engel C, Järvinen HJ, Sampson, Julian R., Karagiannis, JA, Mecklin, JP, Lalloo, F., Engel, C, Capella, G, Bernstein, I., Hodgson SV, Lindblom A, Bertario, L, Jaervinen, Heikki Juhani, Gopie, Jessica P., Karagiannis, John A., Burn, J, Karagiannis JA, Frayling, I.M., Sijmons, Rolf H., Sampson JR, Rahner, N., Ponz de Leon, M, Blanco, I, Aktan Collan K, Møller, P, Hes FJ, Aktan-Collan, K, Blanco, I., Genuardi, Maurizio, Aretz, Stefan, Vasen, HF, Blanco, Ignacio, Nagengast, F.M., Thomas, Huw J. W., Stormorken, A, Lindblom, A., Gopie, J.P., Bertario, L., Moller, Pal, Thomas, H.J.W., Lalloo, Fiona, Rahner N, Renkonen-Sinisalo, Laura, Wijnen, Juul T., Alonso, Angel, Sampson, Julian Roy, Bernstein, Inge, Sijmons, RH, Capella, Gabriel, Mallorca Grp, Jarvinen, H.J., Myrhoj, T, Hes, FJ, Aretz S, Järvinen, HJ, Wijnen, JT, Mallorca group, Vasen, H.F.A., Parc Y, Karagiannis, J.A., Bernstein, I, Hodgson, Shirley V., Rahner, Nils, et al., Parc, Y., Sampson, J.R., Aretz, S, Thomas, H.J., Frayling, Ian M., Capella G, Nagengast FM, Colas, C., Renkonen-Sinisalo, L., Tejpar S, Frayling, IM, Hes, F.J., Renkonen Sinisalo L, Frayling IM, Parc, Y, Mecklin, Jukka-Pekka, Möslein G., de Leon, Maurizio Ponz, Lalloo F, Blanco I, Möslein, G, Hodgson, S.V., Lalloo, F, Heinimann, K., Mecklin, J.P., Colas, C, Thomas, HJ, Colas, Chrystelle, Frayling, Ian Martin, Parc, Yann, Heinimann K, Burn, J., Sijmons, R.H., Stormorken, A., Genuardi M, de Leon, M.P., Colas C, Mecklin JP, Aktan-Collan, K.   +153 more
core   +1 more source

What is currently known about endometrial cancer in Lynch syndrome? - review

Journal of Education, Health and Sport, 2019
Introduction: About 5% of endometrial cancer cases can be genetic and inherited. Lynch syndrome, also called hereditary non-polyposis colorectal cancer (HNPCC), is an autosomal dominant syndrome.
Agnieszka Kwiatkowska, Dominika Krawczyk, Krzysztof Kułak, Sylwester Makuch, Klaudia Sapko   +4 more
doaj   +3 more sources

Novel MSH2 Mutation in the First Report of a Vietnamese–American Kindred with Lynch Syndrome [PDF]

, 2015
•First report of Lynch syndrome in a Vietnamese kindred•A novel MSH2 mutation has been identified.•Culturally sensitive screening programs need to be developed in this growing ...
Wagman, LD, Sandra M. Brown, Eskander, Ramez N, Tewari, KS, Lawrence D. Wagman, Tewari, Krishnansu S., Eskander, R. N., Eskander, RN, Lynch, H. T., Brown, SM, Lynch, Henry T., Wagman, Lawrence D, Wagman, L. D., Brown, Sandra M., Lynch, Henry T, Tewari, Krishnansu S, Wagman, Lawrence D., Brown, S. M., Tewari, K. S., Eskander, Ramez N., Brown, Sandra M, Krishnansu S. Tewari, Lynch, HT, Henry T. Lynch, Ramez N. Eskander   +24 more
core   +1 more source

Case report: Undifferentiated sarcoma with multiple tumors involved in Lynch syndrome: Unexpected favorable outcome to sintilimab combined with chemotherapy

Frontiers in Oncology, 2022
BackgroundPatients with Lynch syndrome are at an increased risk of developing simultaneous or metachronous tumors, while sarcomas have been occasionally reported.
Jiaying Liu, Xiaona Chang, Guixiang Xiao, Jingmin Zhong, Bo Huang, Jiwei Zhang, Beibei Gao, Gang Peng, Xiu Nie   +8 more
doaj   +1 more source

Same Gene Mutation But Variable Phenotypes in 2 Families With Lynch Syndrome: Two Case Reports and Review of Genotype-Phenotype Correlation

Clinical Medicine Insights: Case Reports, 2018
Lynch syndrome is an autosomal dominant syndrome that can be subdivided into Lynch syndrome I, or site-specific colonic cancer, and Lynch syndrome II, or extracolonic cancers, particularly carcinomas of the stomach, endometrium, biliary and pancreatic ...
Raffaella Liccardo, Marina De Rosa, Francesca Duraturo   +2 more
doaj   +1 more source

A Rare Case of Seminoma in an Elderly Patient With Suspected Lynch Syndrome. [PDF]

Clin Case Rep
ABSTRACT Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer, is caused by mutations in the mismatch repair genes and confers genetic predisposition to colorectal and other cancers. Germ cell tumors, the majority of which are seminomas, usually arise sporadically and predominantly occur in younger patients; their association ...
Kamandi M, Boozari M, Soltani E, Soltani S.   +3 more
europepmc   +2 more sources

IDH1 mutated low grade astrocytoma occurring in MSH2 mutated Lynch syndrome family

Human Pathology: Case Reports, 2016
Lynch syndrome (LS) is an autosomal dominant tumour predisposition syndrome caused by a germline mutation in one of the DNA mismatch repair (MMR) genes.Patients with these mutations have an increased risk of brain tumours, the vast majority of which are ...
Alaa Alkhotani, Ingrid Ambus, Lea Velsher, Corwyn Rowsell, Julia Keith   +4 more
doaj   +1 more source

An update on Lynch syndrome

Current Opinion in Oncology, 1998
Recent advances in hereditary nonpolyposis colorectal cancer (HNPCC) have been made based on the discovery early in this decade that germline mutations in genes responsible for repair of DNA mismatches formed the molecular basis for the syndrome. Several studies during the past year described the prevalence of germline mutations in those deemed at risk
H T, Lynch, T, Smyrk
openaire   +3 more sources

Lynch syndrome: An unusal case of familial cancer unearthed

Indian Journal of Pathology and Microbiology, 2022
Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) is a type of inherited cancer syndrome with a genetic predisposition to different types of cancer.
Subhra Dhar, Ashraf U Mannan, J Jaya Singh, Sandipan Dhar, Swetalina Pradhan   +4 more
doaj   +1 more source