Results 21 to 30 of about 31,569 (215)

Endometrial Cancer Diagnosed at an Early Stage during Lynch Syndrome Surveillance: A Case Report

Case Reports in Oncology, 2023
Lynch syndrome is an autosomal dominant inherited disorder caused by a germline pathogenic variant in DNA mismatch repair genes, resulting in multi-organ cancer.
Maki Umemiya, Naoki Horikawa, Ami Kanai, Ayaka Saeki, Kohei Ida, Satoru Makio, Teruki Yoshida, Mitsuru Tsuji, Rei Gou, Hirohiko Tani, Takeshi Usui, Kenzo Kosaka   +11 more
doaj   +1 more source

The prevalence of Lynch syndrome in women with endometrial cancer: a systematic review protocol

Systematic Reviews, 2018
Background Lynch syndrome is the most common inherited cancer syndrome, which predisposes individuals to a number of different cancers, principally colorectal and endometrial cancer.
Neil A. J. Ryan, Dominic Blake, Marcus Cabrera-Dandy, Mark A. Glaire, D. Gareth Evans, Emma J. Crosbie   +5 more
doaj   +1 more source

Development and initial testing of a multi-stakeholder intervention for Lynch syndrome cascade screening: an intervention mapping approach

BMC Health Services Research, 2022
Background Lynch syndrome is an underdiagnosed hereditary condition carrying an increased lifetime risk for colorectal and endometrial cancer and affecting nearly 1 million people in the United States.
Lauren Passero, Swetha Srinivasan, Mary E. Grewe, Jennifer Leeman, Jonathan Berg, Daniel Reuland, Megan C. Roberts   +6 more
doaj   +1 more source

Case Report: A New Subtype of Lynch Syndrome Associated With MSH2 c.1024_1026 Identified in a Chinese Family

Frontiers in Medicine, 2022
BackgroundLynch syndrome is an autosomal dominant disorder associated with a high incidence of various cancer types. Multiple variants of mismatch repair genes have been reported for Lynch syndrome. However, the diagnosis in patients with atypical cancer
Lu Li, Zhe Zhao, Zhe Zhao, Lin Dong, Jia Jia, Ke Su, Hua Bai, Jie Wang   +7 more
doaj   +1 more source

Pathological diagnosis experience and literature review of four cases suspected Lynch-like syndrome

Frontiers in Oncology
BackgroundAmong CRC patients with mismatch repair protein deficiency or microsatellite instability (MSI), up to 50% of cases lack germline mutations in MMR genes, BRAF mutations, or MLH1 promoter methylation. Such cases are defined as Lynch-like syndrome
Bo Cheng, Shan Liu, Shanshan Ding, Lanju Quan, Jinhong Liu, Lin Xu, Huan Zhao, Jing Guo, Suozhu Sun   +8 more
doaj   +1 more source

Differential diagnosis of small bowel occlusions

Clinical Management Issues, 2009
Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, and microsatellite instability (MSI).
Paolo Ghiringhelli
doaj   +1 more source

PD-1 blockage combined with vaccine therapy can facilitate immune infiltration in tumor microenvironment of Lynch syndrome colon cancer

Frontiers in Genetics, 2022
Background: Lynch syndrome is a genetic disease resulting from mismatch repair gene mutation. Vaccine therapy can enhance the immunogenicity of Lynch syndrome and improve the therapeutic efficacy of immunotherapy.
Kai Ye, Wenjin Zhong, Pengcheng Wang, Yanxin Chen, Pan Chi   +4 more
doaj   +1 more source

Association of a novel point mutation in MSH2 gene with familial multiple primary cancers

Journal of Hematology & Oncology, 2017
Background Multiple primary cancers (MPC) have been identified as two or more cancers without any subordinate relationship that occur either simultaneously or metachronously in the same or different organs of an individual. Lynch syndrome is an autosomal
Hai Hu, Hong Li, Feng Jiao, Ting Han, Meng Zhuo, Jiujie Cui, Yixue Li, Liwei Wang   +7 more
doaj   +1 more source

Comprehensive characterization of CRC with germline mutations reveals a distinct somatic mutational landscape and elevated cancer risk in the Chinese population

Cancer Biology & Medicine, 2022
Objective: Hereditary colorectal cancer (CRC) accounts for approximately 5%–10% of all CRC cases. The full profile of CRC-related germline mutations and the corresponding somatic mutational profile have not been fully determined in the Chinese population.
Jianfei Yao, Yunhuan Zhen, Jing Fan, Yuan Gong, Yumeng Ye, Shaohua Guo, Hongyi Liu, Xiaoyun Li, Guosheng Li, Pan Yang, Xiaohui Wang, Danni Liu, Tanxiao Huang, Huiya Cao, Peisu Suo, Yuemin Li, Jingbo Yu, Lele Song   +17 more
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Recent advances in Lynch syndrome

Experimental Hematology & Oncology, 2021
Lynch syndrome is one of the most common hereditary cancer syndromes and is characterized by the development of many cancers, such as colorectal cancer (CRC), endometrial cancer, ovarian cancer, stomach cancer and many other cancers.
Xi Li, Guodong Liu, Wei Wu
doaj   +1 more source