Results 21 to 30 of about 1,289,326 (214)

Novel MSH2 Mutation in the First Report of a Vietnamese–American Kindred with Lynch Syndrome [PDF]

, 2015
•First report of Lynch syndrome in a Vietnamese kindred•A novel MSH2 mutation has been identified.•Culturally sensitive screening programs need to be developed in this growing ...
Wagman, LD, Sandra M. Brown, Eskander, Ramez N, Tewari, KS, Lawrence D. Wagman, Tewari, Krishnansu S., Eskander, R. N., Eskander, RN, Lynch, H. T., Brown, SM, Lynch, Henry T., Wagman, Lawrence D, Wagman, L. D., Brown, Sandra M., Lynch, Henry T, Tewari, Krishnansu S, Wagman, Lawrence D., Brown, S. M., Tewari, K. S., Eskander, Ramez N., Brown, Sandra M, Krishnansu S. Tewari, Lynch, HT, Henry T. Lynch, Ramez N. Eskander   +24 more
core   +1 more source

An Update on Immune Checkpoint Therapy for the Treatment of Lynch Syndrome

Clinical and Experimental Gastroenterology, 2021
Christina Therkildsen,1,2 Lars Henrik Jensen,3 Maria Rasmussen,2 Inge Bernstein4,5 1Department of Surgical Gastroenterology, Copenhagen University Hospital, Copenhagen, Denmark; 2The Danish HNPCC Register, Department of Clinical Research, Copenhagen ...
Therkildsen C, Jensen LH, Rasmussen M, Bernstein I   +3 more
doaj  

Patient-physician relationships, health self-efficacy, and gynecologic cancer screening among women with Lynch syndrome

Hereditary Cancer in Clinical Practice, 2019
Background Lynch syndrome, a hereditary cancer syndrome, predisposes women to colorectal, endometrial, and ovarian cancer. Current guidelines recommend that women with Lynch syndrome undergo risk-reducing gynecological surgery to reduce their chances of ...
Kaitlin M. McGarragle, Melyssa Aronson, Kara Semotiuk, Spring Holter, Crystal J. Hare, Sarah E. Ferguson, Zane Cohen, Tae L. Hart   +7 more
doaj   +1 more source

Lynch syndrome: An unusal case of familial cancer unearthed

Indian Journal of Pathology and Microbiology, 2022
Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) is a type of inherited cancer syndrome with a genetic predisposition to different types of cancer.
Subhra Dhar, Ashraf U Mannan, J Jaya Singh, Sandipan Dhar, Swetalina Pradhan   +4 more
doaj   +1 more source

Development and initial testing of a multi-stakeholder intervention for Lynch syndrome cascade screening: an intervention mapping approach

BMC Health Services Research, 2022
Background Lynch syndrome is an underdiagnosed hereditary condition carrying an increased lifetime risk for colorectal and endometrial cancer and affecting nearly 1 million people in the United States.
Lauren Passero, Swetha Srinivasan, Mary E. Grewe, Jennifer Leeman, Jonathan Berg, Daniel Reuland, Megan C. Roberts   +6 more
doaj   +1 more source

Endometrial Cancer Diagnosed at an Early Stage during Lynch Syndrome Surveillance: A Case Report

Case Reports in Oncology, 2023
Lynch syndrome is an autosomal dominant inherited disorder caused by a germline pathogenic variant in DNA mismatch repair genes, resulting in multi-organ cancer.
Maki Umemiya, Naoki Horikawa, Ami Kanai, Ayaka Saeki, Kohei Ida, Satoru Makio, Teruki Yoshida, Mitsuru Tsuji, Rei Gou, Hirohiko Tani, Takeshi Usui, Kenzo Kosaka   +11 more
doaj   +1 more source

The prevalence of Lynch syndrome in women with endometrial cancer: a systematic review protocol

Systematic Reviews, 2018
Background Lynch syndrome is the most common inherited cancer syndrome, which predisposes individuals to a number of different cancers, principally colorectal and endometrial cancer.
Neil A. J. Ryan, Dominic Blake, Marcus Cabrera-Dandy, Mark A. Glaire, D. Gareth Evans, Emma J. Crosbie   +5 more
doaj   +1 more source

Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome [PDF]

, 2020
BACKGROUND & AIMS: Lynch syndrome is caused by variants in DNA mismatch repair (MMR) genes and associated with an increased risk of colorectal cancer (CRC). In patients with Lynch syndrome, CRCs can develop via different pathways. We studied associations
Dutch Lynch Syndrome Collaborative, Ahadova, Aysel, Finnish Lynch Syndrome Registry, Lepistö, Anna, Renkonen-Sinisalo, Laura, Engel, Christoph, Seppälä, Toni T., Vasen, Hans F., German HNPCC Consortium   +8 more
core   +1 more source

Case Report: A New Subtype of Lynch Syndrome Associated With MSH2 c.1024_1026 Identified in a Chinese Family

Frontiers in Medicine, 2022
BackgroundLynch syndrome is an autosomal dominant disorder associated with a high incidence of various cancer types. Multiple variants of mismatch repair genes have been reported for Lynch syndrome. However, the diagnosis in patients with atypical cancer
Lu Li, Zhe Zhao, Zhe Zhao, Lin Dong, Jia Jia, Ke Su, Hua Bai, Jie Wang   +7 more
doaj   +1 more source

Pathological diagnosis experience and literature review of four cases suspected Lynch-like syndrome

Frontiers in Oncology
BackgroundAmong CRC patients with mismatch repair protein deficiency or microsatellite instability (MSI), up to 50% of cases lack germline mutations in MMR genes, BRAF mutations, or MLH1 promoter methylation. Such cases are defined as Lynch-like syndrome
Bo Cheng, Shan Liu, Shanshan Ding, Lanju Quan, Jinhong Liu, Lin Xu, Huan Zhao, Jing Guo, Suozhu Sun   +8 more
doaj   +1 more source