Results 61 to 70 of about 13,351 (224)
Prognosis prediction of stage IV colorectal cancer patients by mRNA transcriptional profile
Cancer Medicine, Volume 11, Issue 24, Page 4900-4912, December 2022., 2022 This study aimed to clarify the prognostic factors for stage IV CRC patients undergoing primary cancer resection but not liver metastasis resection. WES and RNA‐Seq were used to sequence primary cancer tissues of 78 and 84 patients, respectively. Models were established to stratify the prognosis and to predict individual patient prognosis.
Bian Wu +5 more
wiley +1 more source
Direct estimate of the rate of germline mutation in a bird [PDF]
Genome Research, 2016 The fidelity of DNA replication together with repair mechanisms ensure that the genetic material is properly copied from one generation to another. However, on extremely rare occasions when damages to DNA or replication errors are not repaired, germline mutations can be transmitted to the next generation. Because of the rarity of these events, studying
Smeds, Linnea +2 more
openaire +4 more sources
Impact of germline susceptibility variants in cancer genetic studies [PDF]
arXiv, 2016 Although somatic mutations are the main contributor to cancer, underlying germline alterations may increase the risk of cancer, mold the somatic alteration landscape and cooperate with acquired mutations to promote the tumor onset and/or maintenance.
arxiv
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
Advanced Materials, EarlyView.CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu +4 more
wiley +1 more source
Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis
Cancer Reports, Volume 5, Issue 12, December 2022., 2022 Abstract Background About 50 000 new cases of cancer in the United States are attributed to obesity. The adverse effects of obesity on breast cancer may be most profound when affecting the early development; that is, in the womb of a pregnant obese mother.
Fabia de Oliveira Andrade +2 more
wiley +1 more source
Germline Mutation of INI1/SMARCB1 in Familial Schwannomatosis [PDF]
The American Journal of Human Genetics, 2007 Patients with schwannomatosis develop multiple schwannomas but no vestibular schwannomas diagnostic of neurofibromatosis type 2. We report an inactivating germline mutation in exon 1 of the tumor-suppressor gene INI1 in a father and daughter who both had schwannomatosis.
Hulsebos, T.J.M. +5 more
openaire +4 more sources
Applying BioBERT to Extract Germline Gene-Disease Associations for Building a Knowledge Graph from the Biomedical Literature [PDF]
The 7th International Conference on Information System and Data
Mining (ICISDM2023-ACM), Atlanta, USA, May 2023, 2023 Published biomedical information has and continues to rapidly increase. The recent advancements in Natural Language Processing (NLP), have generated considerable interest in automating the extraction, normalization, and representation of biomedical knowledge about entities such as genes and diseases.
arxiv
Advanced Science, EarlyView.NRAS mutations are widespread in hematologic malignancies. Our study shows that GOLGA7 serves as a safe and effective therapeutic target for NRAS‐driven leukemia. Loss of Golga7 in adult mice effectively suppresses NrasG12D‐driven myeloproliferative neoplasm by disrupting its PM localization and impairing subsequent MAPK signaling, without affecting ...
Bo Jiao +18 more
wiley +1 more source
Molecular testing of soft tissue tumors
Diagnostic Cytopathology, Volume 51, Issue 1, Page 12-25, January 2023., 2023 Abstract Background The diagnosis of soft tissue tumors is challenging, especially when the evaluable material procured is limited. As a result, diagnostic ancillary testing is frequently needed. Moreover, there is a trend in soft tissue pathology toward increasing use of molecular results for tumor classification and prognostication. Hence, diagnosing
Douglas Rottmann +2 more
wiley +1 more source
Predicting B Cell Receptor Substitution Profiles Using Public Repertoire Data [PDF]
, 2018 B cells develop high affinity receptors during the course of affinity maturation, a cyclic process of mutation and selection. At the end of affinity maturation, a number of cells sharing the same ancestor (i.e. in the same "clonal family") are released from the germinal center, their amino acid frequency profile reflects the allowed and disallowed ...
arxiv +1 more source