Results 181 to 190 of about 249,502 (408)
The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC‐derived neurons to amyloid beta and phosphorylated tau‐induced neuronal dysfunction
Alzheimer's &Dementia, EarlyView.Abstract INTRODUCTION
Human tau protein, composed of six brain‐specific isoforms, is a major driver of Alzheimer's disease (AD). The role of its isoforms however remains unclear and human AD models are scarce. METHODS
We generated human MAPT– (tau–) knockout (KO) induced pluripotent stem cells (iPSC) using CRISPR/Cas9, differentiated these into ...Sarah Buchholz, Mohamed Aghyad Al Kabbani, Michael Bell‐Simons, Lena Kluge, Cagla Cagmak, Jennifer Klimek, Natja Haag, Lukas C. Iohan, Audrey Coulon, Marcos R. Costa, Devrim Kilinc, Hans Zempel +11 morewiley +1 more sourceLife's Essential 8 and midlife trajectories in cognition and brain health: The CARDIA study
Alzheimer's &Dementia, EarlyView.Abstract INTRODUCTION
Poor cardiovascular health (CVH) is linked to Alzheimer's disease and dementia; however, its association with neurocognitive trajectories earlier in life remains underexplored. METHODS
We included 3224 participants with information on CVH at early midlife (mean age 45.0 ± standard deviation 3.4) an cognitive assessments, and ...Christina Silvia Dintica, Xiaqing Jiang, Lenore J. Launer, R. Nick Bryan, Kristine Yaffe +4 morewiley +1 more sourceBLITZ‐HF: a nationwide initiative to evaluate and improve adherence to acute and chronic heart failure guidelines
European Journal of Heart Failure, Volume 24, Issue 11, Page 2078-2089, November 2022., 2022 Aims
To assess adherence to guideline recommendations among a large network of Italian cardiology sites in the management of acute and chronic heart failure (HF) and to evaluate if an ad‐hoc educational intervention can improve their performance on several pharmacological and non‐pharmacological indicators.Michele Massimo Gulizia, Francesco Orso, Andrea Mortara, Donata Lucci, Nadia Aspromonte, Leonardo De Luca, Giuseppe Di Tano, Giuseppe Leonardi, Alessandro Navazio, Giovanni Pulignano, Furio Colivicchi, Andrea Di Lenarda, Fabrizio Oliva, on behalf of
BLITZ‐HF Investigators, G. Pajes, A.R. Felici, P. Midi, G. Leonardi, G. Montana, V. Randazzo, E. Guerri, E. Lo Jacono, V. Zanasi, C. Leuzzi, V. Rizzello, A. Battagliese, N. Pagnoni, G. Pulignano, M. Uguccioni, M.D. Tinti, G.M. Frigo, M. Anselmi, E. Zorzi, I. Battistoni, G.P. Perna, L. Prosseda, M. Pulcini, C. Pellizzari, C. Paolini, G. Bardelli, R. Panciarola, B. Bordoni, S. Urbinati, C. Pedone, C. Greco, E.R. Cosentino, C. Borghi, C. Cuccia, L. Caprini, C. Mariani, C. Borghi, E. Benvenuto, M.B. Zisa, G.M. Francese, M.M. Gulizia, M. Bartolotti, M. Marconi, D. Severini, K. Mboumi, E. Capati, F. Venturi, E. Savini, D. Gabrielli, A. Herbst, F. Orso, F. Sani, C. Minneci, E. Gardini, D. Nanni, C. Lirato, F. Piemonte, P. Ameri, M. Canepa, F. Mainardi, R. Ghinazzi, F. Poletti, C. Inserra, S. Arcidiacono, V. Crisci, C.C. De Carlini, S. Maggiolini, F. Napoli, A.G. Versace, I. Di Matteo, A. Sacco, A.F. Giglio, M.G. Cipriani, G. Mombelli, A. Alberti, V. Antonazzo, O. Agostoni, G. Riboni, G. Guazzotti, S. Mazzetti, A. Mortara, L. Montagna, M.G. Perrelli, L. Scelsi, S. Ghio, A. Gualco, C. Opasich, L. Filippucci, A. Burini, I. Puggia, E. Loiudice, G. Iabichella, A. Nicosia, A. Frisinghelli, G. De Angelis, P. Del Corso, F. Marzo, S. Carigi, G. Piovaccari, S. Refice, T. Nejat, S.A. Di Fusco, F. Colivicchi, D. Pini, P. Romano, G. Padula, A. Gigantino, L. Spera, A. Pagliaro, L.L. Piccioni, C. Napoletano, C. Calcagnile, P. Sbarra, D. Belloli, P.C. Sganzerla, M. Merlo, V. De Paris, M. Driussi, D. Miani, C.A. Gianonatti, L. Moretti, G. Licciardello, V. Palmieri, P. Costa, S. Zingaro, L. Tedesco, A. Iacovoni, M. Liotino, A. Ravera, A. De Castro, G. Rossetti, M. Corda, D. Armata, G. Vianello, E. Pelissero, G. Ruberti, S. D'Orazio, C. Pedrinazzi, D. Robba, A. Carbone, F. De Cian, A. Fucili, F. Grossi, N.D. Brunetti, C. Minoia, M. Pernigo, S. Costa, L. Esposito, G. Senatore, P. Pelaggi, R. Poddighe, E. Zanelli, L. Salvini, G. Galati, A. Zanocco, M. Cannillo, A. Vincenzi, M.A. Losi, L. Caliendo, V. Orrù, E. Carluccio, L. Garritano, E. Garelli, R. Poletti, M. Taglioli, G. Scopelliti, M. Lo Presti, C. Gardini, S. Iosi, C. Tota, M. Mancone, C. De Matteis, F. Rusconi, M.A. Ammirati, G. Cicia, S. Meloni, F. Menozzi, A. Cafro, M. Ribezzo, I. Parrini, S. Giacomelli, G. Russo, F. Morandi, F. Sturniolo +197 morewiley +1 more sourcePremenopausal bilateral oophorectomy and Alzheimer's disease imaging biomarkers later in life
Alzheimer's &Dementia, EarlyView.Abstract INTRODUCTION
Premenopausal bilateral oophorectomy (PBO) before the age of 46 years is associated with an increased risk of dementia. We investigated the long‐term effects of PBO performed before age 50 years on amyloid beta (Aβ), tau, and neurodegeneration imaging biomarkers of Alzheimer's disease (AD).Kejal Kantarci, Ekta Kapoor, Jennifer R. Geske, Anna Castillo, Julie A. Fields, Firat Kara, Evdokiya E. Knyazhanskaya, Christopher G. Schwarz, Matthew L. Senjem, Kent R. Bailey, Val Lowe, Nathan K. LeBrasseur, Walter A. Rocca, Michelle M. Mielke +13 morewiley +1 more sourceMyocarditis following COVID‐19 vaccine: incidence, presentation, diagnosis, pathophysiology, therapy, and outcomes put into perspective. A clinical consensus document supported by the Heart Failure Association of the European Society of Cardiology (ESC) and the ESC Working Group on Myocardial and Pericardial Diseases
European Journal of Heart Failure, Volume 24, Issue 11, Page 2000-2018, November 2022., 2022 Overview on incidence, diagnosis, and therapy in vaccine‐related myocarditis. CMR, cardiac magnetic resonance; EMB, endomyocardial biopsy; NSAIDS, non‐steroidal anti‐inflammatory drugs. Abstract
Over 10 million doses of COVID‐19 vaccines based on RNA technology, viral vectors, recombinant protein, and inactivated virus have been administered worldwide. Bettina Heidecker, Noa Dagan, Ran Balicer, Urs Eriksson, Giuseppe Rosano, Andrew Coats, Carsten Tschöpe, Sebastian Kelle, Gregory A. Poland, Andrea Frustaci, Karin Klingel, Pilar Martin, Joshua M. Hare, Leslie T. Cooper, Antonis Pantazis, Massimo Imazio, Sanjay Prasad, Thomas F. Lüscher +17 morewiley +1 more sourceAgeing, meaning and social structure : connecting critical and humanistic gerontology [PDF]
, 2015 Book review of Baars, J., Dohmen, J., Grenier, A. and Phillipson, C. (eds.) (2013). Ageing, meaning and social structure: Connecting critical and humanistic gerontology.N/Formosa, Marvincore
