Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden +15 more
wiley +1 more source
Characterisation of placental malaria in olive baboons (Papio anubis) infected with Plasmodium knowlesi H strain [PDF]
Int. J. Integ. Biol: Year 2012 Volume 9, Issue No. 2: 54 - 58, 2012 Pregnant women have increased susceptibility to malaria infection. In these women, malaria parasites are frequently found sequestered in the placental intervillous spaces, a condition referred to as placental malaria (PM). Placental malaria threatens the health of the mother and the child's life by causing still births and reduction in gestational age.
arxiv
Generating functionals and Gaussian approximations for interruptible delay reactions [PDF]
, 2015 We develop a generating functional description of the dynamics of non-Markovian individual-based systems, in which delay reactions can be terminated before completion. This generalises previous work in which a path-integral approach was applied to dynamics in which delay reactions complete with certainty.
arxiv +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective People with HIV (PWH) on antiretroviral therapy (ART) still experience neurocognitive dysfunction and accelerated brain volume loss. To assess whether the serotonergic and dopaminergic systems are affected, we used [11C]DASB positron emission tomography (PET) to assess presynaptic serotonergic function and [18F]FDOPA PET to measure ...
Chuen‐Yen Lau +12 more
wiley +1 more source
Monotone function estimation in the presence of extreme data coarsening: Analysis of preeclampsia and birth weight in urban Uganda [PDF]
arXiv, 2019 This paper proposes a Bayesian hierarchical model to characterize the relationship between birth weight and maternal pre-eclampsia across gestation at a large maternity hospital in urban Uganda. Key scientific questions we investigate include: 1) how pre-eclampsia compares to other maternal-fetal covariates as a predictor of birth weight; and 2 ...
arxiv
Effect of housing on rubber slat mats during pregnancy on the behaviour and welfare of sows in farrowing crates [PDF]
, 2014 peer-reviewedThe aim of this study was to evaluate the effect of flooring type during gestation, lameness and limb lesion scores on welfare and behaviour of sows in farrowing crates. Sixty sows group-housed during gestation in pens with solid concrete
Boyle, Laura, Calderon Diaz, Julia
core
Serum relaxin levels are reduced in pregnant women with a history of recurrent miscarriage, and correlate with maternal uterine artery Doppler indices in first trimester [PDF]
, 2009 Objectives: Defective implantation is a mechanism for recurrent pregnancy loss (RPL). We sought to determine whether the serum expression of human relaxin-2 (RLX) is impaired in women with a history of RPL.
Bogic +30 more
core +1 more source
Translating Muscle RNAseq Into the Clinic for the Diagnosis of Muscle Diseases
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Approximately half of patients with hereditary myopathies remain without a definitive genetic diagnosis after DNA next‐generation sequencing (NGS). Here, we implemented transcriptome analysis of muscle biopsies as a complementary diagnostic tool for patients with muscle disease but no definitive genetic diagnosis after exome ...
Alba Segarra‐Casas +24 more
wiley +1 more source
Consumer Preferences for Animal Welfare Attributes: The Case of Gestation Crates [PDF]
Animal welfare concerns are having dramatic impacts on food and livestock markets. Here we examine consumer preferences for pork products with a focus on use of gestation crates.
Olynk, Nicole J. +2 more
core +1 more source
Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas. [PDF]
, 2019 Congenital human cytomegalovirus (HCMV) infection is a leading cause of birth defects worldwide, yet the most effective strategies for preventing virus transmission during pregnancy are unknown.
An, Zhiqiang +8 more
core +1 more source