Results 91 to 100 of about 495,711 (312)

Developmentally Guided Differentiation of Ventral Midbrain Dopaminergic Cells Validated in Proteopathy‐Based Parkinson's Disease Models

Advanced Science, EarlyView.
A developmentally guided protocol reproducibly specifies EN1‐positive ventral midbrain dopaminergic (vmDA) progenitors from human pluripotent stem cells and yields functional vmDA neurons. Optogenetic induction of α‐synuclein aggregation elicits selective degeneration of TH‐positive neurons in 2D cultures and 3D neurospheroids, while transplanted ...
Heechang Moon, Heejeong Kim, Elliot H. Lee, Hanseul Kim, Ji Hun Kim, Huisu Jeong, Jiwon Cheon, Ga Ram Jeong, Byoung Dae Lee, Jae‐Won Cho, Soo‐Jin Oh, Yunjong Lee, Yohan Oh   +12 more
wiley   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Human placental growth hormone is increased in maternal serum at 20 weeks of gestation in pregnancies with large-for-gestational-age babies

, 2017
To investigate the relationship between maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF)-1 and 2, IGF binding proteins (IGFBP)-1 and 3 and birth weight in appropriate-for-gestational-age (AGA), large-for ...
Beatrix Jones (3696325), Mark H. Vickers (6899263), Shutan Liao (3696328), Rennae S. Taylor (7739246), Jo K. Perry (3696319), Mhoyra Fraser (3696322), Lesley M. E. McCowan (7710743), Philip N. Baker (338976)   +7 more
core   +3 more sources

Outpatient screening for gestational diabetes mellitus [PDF]

Einstein (São Paulo), 2006
Objective: To screen for gestational diabetes mellitus inoutpatients, with 50 g oral glucose load, comparing capillary(reflectance) and venous plasma (enzymatic) glucose.
José Eduardo Gobbi Lima, Umberto Gazi Lippi   +1 more
doaj  

Association of copeptin levels in the postpartum period with gestational diabetes [PDF]

Archives of Endocrinology and Metabolism
Objective: To investigate the association of copeptin levels in the postpartum period with previous gestational diabetes mellitus, as well as its cardiometabolic phenotypes and biomarkers.
Sofia Duarte Soares, Patricia Medici Dualib, Fernando de Mello Almada Giuffrida, Bianca de Almeida-Pititto, André Fernandes Reis   +4 more
doaj   +1 more source

Symphysis-fundal height to identify large-for-gestational-age and macrosomia: a meta-analysis

, 2019
Bivariate diagnostic meta-analysis was performed to evaluate the diagnostic value of symphysis-fundal height (SFH) for identifying large-for-gestational- age (LGA) (i.e. birth weight >90th centile according to gestational age) and macrosomia (i.e.
Eita Goto (8101688)
core   +1 more source

Adjusted analysis of risk of large-for-gestational-age, total cesarean section and operative vaginal delivery after excluding women with a GDM diagnosis based on WHO-1999 criteria.

, 2023
Adjusted analysis of risk of large-for-gestational-age, total cesarean section and operative vaginal delivery after excluding women with a GDM diagnosis based on WHO-1999 criteria.
Line Sletner (292376), Signe Nilssen Stafne (5089160), Are Hugo Pripp (7356923), Nina Cecilie Øverby (11410151), Linda Reme Sagedal (4621729), Anam Shakil Rai (16503263), Anne Karen Jenum (9535089), Elisabeth Qvigstad (398475)   +7 more
core   +1 more source

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

Advanced Science, EarlyView.
COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu, Lingling Xie, Wenyi Liu, Hanjie Mo, Chengshu Xie, Jing Tang, Zhaorui Wang, Peixuan Lan, Jianping Zhang, Jie Gao, Qionglan Tang, Chunwei Cao, Hui Chen   +12 more
wiley   +1 more source

Comparison of Serum Homocystein and Folic Acid Levels in Gestational Diabetes with Normal Pregnancy

پزشکی بالینی ابن سینا, 2015
Introduction & Objective: High levels of homocystein are a risk factor for insulin resistance, diabetes mellitus and cardio-vascular complications. This study was done to assess serum homocystein and folic acid levels and their relationship in women with
Farideh Movahed, Ezzatosadat Hajiseyedjavadi, Nahid Safari, Zohreh Yazdi   +3 more
doaj